Nanohybrid systems of non-ionic surfactant inserting liposomes loading paclitaxel for reversal of multidrug resistance
文献类型：期刊论文
| 作者 | Ji, Xiufeng1,2; Gao, Yu2; Chen, Lingli2 ; Zhang, Zhiwen2; Deng, Yihui1; Li, Yaping2
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| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2012-01-17 |
| 卷号 | 422期号:1-2页码:390-397 |
| 关键词 | Nanohybrid systems Non-ionic surfactant Liposome Multi-drug resistance Paclitaxel |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2011.10.003 |
| 文献子类 | Article |
| 英文摘要 | Three new nanohybrid systems of non-ionic surfactant inserting liposomes loading paclitaxel (PTX) (NLPs) were prepared to overcome multidrug resistance (MDR) in PTX-resistance human lung cancer cell line. Three non-ionic surfactants, Solutol (R) HS 15 (HS-15), pluronic F68 (PF-68) and cremophor EL (CrEL) were inserted into liposomes by film hydration method to form NLPs with an average size of around 110, 180 and 110 nm, respectively. There was an obvious increase of rhodamin 123 (Rh123) accumulation in A549/T cells after treated with nanohybrid systems loading Rh123 (NLRs) when compared with free Rh123 or liposomes loading Rh123 without surfactants (LRs), which indicated the significant inhibition effects of NLRs on drug efflux. The P-gp detection and ATP determination demonstrated that BNLs could not only interfere P-gp expression on the membrane of drug resistant cells, but also decrease ATP level in the cells. The cytotoxicity of NLPs against A549/T cells was higher than PTX loaded liposomes without surfactants (LPs), and the best result was achieved after treated with NLPs2. The apoptotic assay and the cell cycle analysis showed that NLPs could induce more apoptotic cells in drug resistant cells when compared with LPs. These results suggested that NLPs could overcome MDR by combination of drug delivery, P-gp inhibition and ATP depletion, and showed potential for treatment of MDR. (c) 2011 Elsevier B.V. All rights reserved. |
| WOS关键词 | PLURONIC BLOCK-COPOLYMERS ; P-GLYCOPROTEIN ; CANCER-CELLS ; DRUG-RESISTANCE ; IN-VITRO ; TRANSPORTERS ; EFFLUX ; TAXOL ; DOXORUBICIN ; PROTEIN |
| 资助项目 | National Basic Research Program of China[2010CB934000] ; National Basic Research Program of China[2011CB933100] ; National Natural Science Foundation of China[30925041] ; National Natural Science Foundation of China[30873169] ; Shanghai Elitist Program[11XD1406200] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000302398700049 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278214]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Li, Yaping |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Ji, Xiufeng,Gao, Yu,Chen, Lingli,et al. Nanohybrid systems of non-ionic surfactant inserting liposomes loading paclitaxel for reversal of multidrug resistance[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2012,422(1-2):390-397. |
| APA | Ji, Xiufeng,Gao, Yu,Chen, Lingli,Zhang, Zhiwen,Deng, Yihui,&Li, Yaping.(2012).Nanohybrid systems of non-ionic surfactant inserting liposomes loading paclitaxel for reversal of multidrug resistance.INTERNATIONAL JOURNAL OF PHARMACEUTICS,422(1-2),390-397. |
| MLA | Ji, Xiufeng,et al."Nanohybrid systems of non-ionic surfactant inserting liposomes loading paclitaxel for reversal of multidrug resistance".INTERNATIONAL JOURNAL OF PHARMACEUTICS 422.1-2(2012):390-397. |
入库方式： OAI收割
来源：上海药物研究所
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