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Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles
文献类型：期刊论文
| 作者 | Gao, Yu1; Chen, Yu2; Ji, Xiufeng1; He, Xinyu1; Yin, Qi1 ; Zhang, Zhiwen1; Shi, Jianlin2; Li, Yaping1
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| 刊名 | ACS NANO
 |
| 出版日期 | 2011-12 |
| 卷号 | 5期号:12页码:9788-9798 |
| 关键词 | multidrug resistance hollow mesoporous silica nanoparticles pore size drug delivery doxorubicin |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/nn2033105 |
| 文献子类 | Article |
| 英文摘要 | In this work, hollow mesoporous silica nanoparticles (HMSNs) with three pore sizes were manufactured to control the drug release rate, and the biological roles of these HMSNs were evaluated in multidrug-resistant (MDR) cancer cells. As novel pore-size-controllable inorganic materials, HMSNs showed negligible cytotoxicity and efficient cellular uptake toward drug-sensitive MCF-7 and drug-resistant MCF-7/ADR cells. Doxorubicin (DOX)-loaded HMSNs (DMSNs) not only demonstrated effective drug loading and a pH-responsive drug release character but also exhibited pore-size-dependent and sustained drug release performance in both in vitro and intracellular drug release experiments. In addition, DMSNs exhibited pore-size-dependent anticancer activity against MCF-7/ADR cells. DMSNs with larger pore size could mediate more cellular uptake of DOX and faster intracellular drug release, which led to more intracellular drug accumulation and stronger MDR-reversal effects. The MDR-overcoming mechanism could be due to the efficient cellular uptake, P-gp inhibition, and ATP depletion. These results demonstrate that HMSNs could be a very promising drug delivery system for pore-size-controllable drug release and cancer MDR reversion. |
| WOS关键词 | ANTICANCER DRUGS ; DELIVERY-SYSTEMS ; THERAPY ; NANOCAPSULES ; CHEMOTHERAPY ; EFFICACY ; CARRIERS ; SIRNA |
| 资助项目 | National Basic Research Program of China[2010CB934000] ; National Basic Research Program of China[2009CB930304] ; National Basic Research Program of China[2012CB932500] ; National Natural Science Foundation of China[30925041] ; National Natural Science Foundation of China[50823007] ; Science and Technology Commission of Shanghai[10430712800] ; Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures[SKL201001] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000298316700051 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278308]  |
| 专题 | 药物制剂研究中心 上海中药现代化研究中心 |
| 通讯作者 | Shi, Jianlin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Gao, Yu,Chen, Yu,Ji, Xiufeng,et al. Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles[J]. ACS NANO,2011,5(12):9788-9798. |
| APA | Gao, Yu.,Chen, Yu.,Ji, Xiufeng.,He, Xinyu.,Yin, Qi.,...&Li, Yaping.(2011).Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles.ACS NANO,5(12),9788-9798. |
| MLA | Gao, Yu,et al."Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles".ACS NANO 5.12(2011):9788-9798. |
入库方式： OAI收割
来源：上海药物研究所
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