Solid lipid nanoparticles reduce systemic toxicity of docetaxel: Performance and mechanism in animal
文献类型：期刊论文
| 作者 | Gao, Yu1; Yang, Rongfu2,3; Zhang, Zhiwen1 ; Chen, Lingli1; Sun, Zuyue2,3; Li, Yaping1
|
| 刊名 | NANOTOXICOLOGY
 |
| 出版日期 | 2011-12 |
| 卷号 | 5期号:4页码:636-649 |
| 关键词 | Nanotoxicity nanoparticles docetaxel nanomedicine toxicity |
| ISSN号 | 1743-5390 |
| DOI | 10.3109/17435390.2010.551427 |
| 文献子类 | Article |
| 英文摘要 | Nanotechnology presents great potential for increasing efficacy of docetaxel while reducing side-effects and toxicity. However, in vivo toxicity of nano-formulation of docetaxel has not been systemically investigated yet. Herein, the new docetaxel-loaded solid lipid nanoparticles (DSNs) were prepared, and systemic toxicity of DSNs in different animals was comprehensively investigated. The experimental results showed that no allergenicity and vascular irritation were induced by DSNs at the highest drug concentration of clinical infusion. The maximum tolerated dose (MTD) of DSNs was as high as 400 mg/kg in mice while the medial lethal dose (LD50) of Taxotere (R) was 149.31 mg/kg. The long-term toxicity of DSNs compared with Taxotere (R) in beagle dogs by intravenous infusion weekly for four weeks showed that the administration of Taxotere (R) at 1 mg/kg brought about severe signs of toxicity such as skin flushing, vocalization and salivation. However, no abnormal reactions appeared on animals treated with DSNs at dose of 4 mg/kg. At the same dose level, DSNs induced more minor decreases in body weight gains, slighter hemotoxicity (changes in some clinical hematology and biochemistry parameters), cardiac toxicity, hepatotoxicity and myelosuppression than Taxotere (R). These results could provide an important reference for developing the novel delivery system of docetaxel. |
| WOS关键词 | METASTATIC BREAST-CANCER ; IN-VIVO ; DELIVERY ; CHEMOTHERAPY ; EFFICACY ; PHARMACOKINETICS ; BIODISTRIBUTION ; NANOTOXICOLOGY ; CYTOTOXICITY ; FORMULATIONS |
| 资助项目 | National Basic Research Program of China[2010CB934000] ; National Basic Research Program of China[2007CB935800] ; National Natural Science Foundation of China[30925041] ; National Natural Science Foundation of China[30901866] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2009ZX09501-024-] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2009ZX09301-001] ; CAS[KSCX2-YW-R-193] |
| WOS研究方向 | Science & Technology - Other Topics ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000296633100015 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278324]  |
| 专题 | 药物制剂研究中心 上海中药现代化研究中心 |
| 通讯作者 | Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Natl Evaluat Ctr Toxicol Fertil Regulating Drugs, Shanghai, Peoples R China 3.Shanghai Inst Planned Parenthood Res, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Gao, Yu,Yang, Rongfu,Zhang, Zhiwen,et al. Solid lipid nanoparticles reduce systemic toxicity of docetaxel: Performance and mechanism in animal[J]. NANOTOXICOLOGY,2011,5(4):636-649. |
| APA | Gao, Yu,Yang, Rongfu,Zhang, Zhiwen,Chen, Lingli,Sun, Zuyue,&Li, Yaping.(2011).Solid lipid nanoparticles reduce systemic toxicity of docetaxel: Performance and mechanism in animal.NANOTOXICOLOGY,5(4),636-649. |
| MLA | Gao, Yu,et al."Solid lipid nanoparticles reduce systemic toxicity of docetaxel: Performance and mechanism in animal".NANOTOXICOLOGY 5.4(2011):636-649. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。