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A self-assembled nanodelivery system enhances the oral bioavailability of daidzein: in vitro characteristics and in vivo performance

文献类型：期刊论文

作者Zhang, Zhiwen1; Huang, Yan1,3; Gao, Fang1,2; Gao, Zhiwei1; Bu, Huihui1; Gu, Wangwen1; Li, Yaping1
刊名NANOMEDICINE
出版日期2011-10
卷号6期号:8页码:1365-1379
关键词bioavailability daidzein intestinal absorption mixed micelle oral delivery
ISSN号1743-5889
DOI10.2217/NNM.11.39
文献子类Article
英文摘要A self-assembled nano-based delivery system was designed and developed to increase the oral bioavailability of poor hydrophilic and lipophilic daidzein. Methods: Daidzein was firstly combined with lecithin to form the daidzein-lecithin complex, then self-assembled into micelles (DLMs) with lecithin and sodium bile. The physiochemical properties and intestinal absorption of DLMs were characterized, and the pharmacokinetic behavior was evaluated in rats. Results: DLMs exhibited nanometer-sized particles. DLMs were mainly distributed in the stomach and proximal intestine after oral administration. The intestinal absorption of DLMs was significantly improved, and DLMs could be absorbed via both endocytosis and passive transport. The AUC(0-t) value of daidzein in rats treated with DLMs was ninefold greater than that of free daidzein suspension. Conclusion: The presented delivery system could provide a new promising strategy for enhancing the oral bioavailability of drugs with poor hydrophilicity and lipophilicity.
WOS关键词SOLID LIPID NANOPARTICLES ; SOY ISOFLAVONES ; MIXED MICELLES ; LIPOPHILIC DRUGS ; DELIVERY-SYSTEMS ; RATS ; FORMULATION ; GENISTEIN ; LYSOPHOSPHATIDYLCHOLINE ; PHARMACOKINETICS
资助项目The National Basic Research Program of China[2009CB930304] ; The National Basic Research Program of China[2007CB935800] ; National Natural Science Foundation of China[30925041] ; National Natural Science Foundation of China[30901866] ; Shanghai Nanomedicine Program[1052nm06300] ; National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2009ZX09501-024] ; National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2009ZX09301-001]
WOS研究方向Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
语种英语
WOS记录号WOS:000296605900017
出版者FUTURE MEDICINE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/278377]  
专题药物制剂研究中心
通讯作者Li, Yaping
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
2.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China
3.Jiangsu Univ, Dept Pharmaceut, Sch Pharm, Zhenjiang 212013, Peoples R China;
推荐引用方式
GB/T 7714		 Zhang, Zhiwen,Huang, Yan,Gao, Fang,et al. A self-assembled nanodelivery system enhances the oral bioavailability of daidzein: in vitro characteristics and in vivo performance[J]. NANOMEDICINE,2011,6(8):1365-1379.
APA Zhang, Zhiwen.,Huang, Yan.,Gao, Fang.,Gao, Zhiwei.,Bu, Huihui.,...&Li, Yaping.(2011).A self-assembled nanodelivery system enhances the oral bioavailability of daidzein: in vitro characteristics and in vivo performance.NANOMEDICINE,6(8),1365-1379.
MLA Zhang, Zhiwen,et al."A self-assembled nanodelivery system enhances the oral bioavailability of daidzein: in vitro characteristics and in vivo performance".NANOMEDICINE 6.8(2011):1365-1379.

入库方式： OAI收割

来源：上海药物研究所

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