热门
A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance
文献类型：期刊论文
| 作者 | He, Qianjun2; Gao, Yu1; Zhang, Lingxia2; Zhang, Zhiwen1 ; Gao, Fang1; Ji, Xiufeng1; Li, Yaping1; Shi, Jianlin2
|
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2011-10 |
| 卷号 | 32期号:30页码:7711-7720 |
| 关键词 | Mesoporous silica Nanoparticle Controlled drug release Multi-drug delivery One-pot self-assembly Multi-drug resistance |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2011.06.066 |
| 文献子类 | Article |
| 英文摘要 | A type of pH-responsive nano multi-drug delivery systems (nano-MDDSs) with uniform particle size (100 +/- 13 nm) and excellent monodispersity was developed by in situ co-self-assembly among water-insoluble anti-cancer drug (doxorubicin, DOX), surfactant micelles (CTAB) as chemosensitiver and silicon species forming drugs/surfactant micelles-co-loaded mesoporous silica nanoparticles (drugs@micelles@MSNs or DOX@CTAB@MSNs) via a micelles-MSNs self-assembly mechanism. The nano-MDDS DOX@CTAB@MSNs had a highly precise pH-responsive drug release behavior both in vitro and in vivo, and exhibited high drug efficiencies against drug-resistant MCF-7/ADR cells as well as drug-sensitive MCF-7 cells by the MSNs-mediated transmembrane delivery, the sustained drug release and the high anti-cancer and multi-drug resistance (MDR)-overcoming efficiencies. The MDR-overcoming mechanism was proved to be a synergistic cell cycle arrest/apoptosis-inducing effect resulted from the chemosensitization of the surfactant CTAB. These results demonstrated a very promising nano-MDDS for the pH-responsive controlled drug release and the cancer MDR overcoming. (C) 2011 Elsevier Ltd. All rights reserved. |
| WOS关键词 | DRUG-DELIVERY ; CARCINOMA CELLS ; IN-VITRO ; CANCER ; RELEASE ; GLYCOPROTEIN ; STRATEGIES |
| 资助项目 | NSFC[50823007] ; NSFC[50972154] ; NSFC[51072212] ; National Basic Research Program of China[2011CB707905] ; National Basic Research Program of China[2010CB934000] ; Science and Technology Commission of Shanghai[10430712800] ; CASKJCX[KJCX2-YW-210] ; Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures[SKL201001] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000294829300044 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278391]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Qianjun,Gao, Yu,Zhang, Lingxia,et al. A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance[J]. BIOMATERIALS,2011,32(30):7711-7720. |
| APA | He, Qianjun.,Gao, Yu.,Zhang, Lingxia.,Zhang, Zhiwen.,Gao, Fang.,...&Shi, Jianlin.(2011).A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance.BIOMATERIALS,32(30),7711-7720. |
| MLA | He, Qianjun,et al."A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance".BIOMATERIALS 32.30(2011):7711-7720. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。