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In vivo Biodistribution and Urinary Excretion of Mesoporous Silica Nanoparticles: Effects of Particle Size and PEGylation
文献类型：期刊论文
| 作者 | He, Qianjun2; Zhang, Zhiwen1 ; Gao, Fang1; Li, Yaping1; Shi, Jianlin2
|
| 刊名 | SMALL
 |
| 出版日期 | 2011-01-17 |
| 卷号 | 7期号:2页码:271-280 |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201001459 |
| 文献子类 | Article |
| 英文摘要 | The in vivo biodistribution and urinary excretion of spherical mesoporous silica nanoparticles (MSNs) are evaluated by tail-vein injection in ICR mice, and the effects of the particle size and PEGylation are investigated. The results indicate that both MSNs and PEGylated MSNs of different particle sizes (80-360 nm) distribute mainly in the liver and spleen, a minority of them in the lungs, and a few in the kidney and heart. The PEGylated MSNs of smaller particle size escape more easily from capture by liver, spleen, and lung tissues, possess longer blood-circulation lifetime, and are more slowly biodegraded and correspondingly have a lower excreted amount of degradation products in the urine. Neither MSNs nor PEGylated MSNs cause tissue toxicity after 1 month in vivo. |
| WOS关键词 | DRUG-DELIVERY ; CONTROLLED-RELEASE ; HEMOLYTIC-ACTIVITY ; TOXICITY ; NANOMATERIALS ; CYTOTOXICITY ; RATS ; MICE |
| 资助项目 | National Nature Science Foundation of China[50823007] ; National Nature Science Foundation of China[50972154] ; National Basic Research Program of China[2010CB934000] ; National Basic Research Program of China[2009CB930304] ; National 863 High-Tech Program[2007AA03Z317] ; Science and Technology Commission of Shanghai[10430712800] ; CASKJCX[KJCX2-YW-M02] ; CASKJCX[KJCX2-YW-210] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000286997600017 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278624]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Qianjun,Zhang, Zhiwen,Gao, Fang,et al. In vivo Biodistribution and Urinary Excretion of Mesoporous Silica Nanoparticles: Effects of Particle Size and PEGylation[J]. SMALL,2011,7(2):271-280. |
| APA | He, Qianjun,Zhang, Zhiwen,Gao, Fang,Li, Yaping,&Shi, Jianlin.(2011).In vivo Biodistribution and Urinary Excretion of Mesoporous Silica Nanoparticles: Effects of Particle Size and PEGylation.SMALL,7(2),271-280. |
| MLA | He, Qianjun,et al."In vivo Biodistribution and Urinary Excretion of Mesoporous Silica Nanoparticles: Effects of Particle Size and PEGylation".SMALL 7.2(2011):271-280. |
入库方式： OAI收割
来源：上海药物研究所
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