Investigation of piceid metabolites in rat by liquid chromatography tandem mass spectrometry
文献类型：期刊论文
| 作者 | Wang, Donggeng3; Zhang, Zhiwen1 ; Ju, Jianfeng2; Wang, Xinyang3; Qiu, Wenjing3
|
| 刊名 | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
 |
| 出版日期 | 2011 |
| 卷号 | 879期号:1页码:69-74 |
| 关键词 | Piceid HPLC-MS-MS In vitro metabolism Urinary metabolite |
| ISSN号 | 1570-0232 |
| DOI | 10.1016/j.jchromb.2010.11.012 |
| 文献子类 | Article |
| 英文摘要 | There is considerable evidence that stilbenes provide health benefits. Trans-piceid is one of the major stilbenoid compounds in red wine and other plants. The purpose of this study is to investigate the metabolism of piceid in rats, including its conversion product by intestinal microflora in vitro and urinary metabolites. A HPLC-MS/MS method with electrospray ionization (ESI), negative ion mode and collision induced dissociation (CID), was used to elucidate the structures of the major metabolites of piceid. Three metabolites resveratrol, dihydropiceid and dihydroresveratrol were detected after incubating with gut microbiota for 5 h. Four urinary metabolites of piceid were identified as resveratrol, dihydroresveratrol monosulfate, piceid monosulfate and piceid monoglucuronide. (C) 2010 Published by Elsevier B.V. |
| WOS关键词 | TRANS-RESVERATROL ; IDENTIFICATION ; AGGREGATION ; PLASMA |
| 资助项目 | Natural Science Foundation of Jiangsu College University[08KJB150013] ; National Program on Key Basic Research Project[2009CB930300] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000286539900010 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278660]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Wang, Donggeng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China; 2.Nantong Univ, Sch Chem & Chem Engn, Nan Tong 226001, Peoples R China 3.Nantong Univ, Sch Med, Nan Tong 226001, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Donggeng,Zhang, Zhiwen,Ju, Jianfeng,et al. Investigation of piceid metabolites in rat by liquid chromatography tandem mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2011,879(1):69-74. |
| APA | Wang, Donggeng,Zhang, Zhiwen,Ju, Jianfeng,Wang, Xinyang,&Qiu, Wenjing.(2011).Investigation of piceid metabolites in rat by liquid chromatography tandem mass spectrometry.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,879(1),69-74. |
| MLA | Wang, Donggeng,et al."Investigation of piceid metabolites in rat by liquid chromatography tandem mass spectrometry".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 879.1(2011):69-74. |
入库方式： OAI收割
来源：上海药物研究所
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