Daidzein-phospholipid complex loaded lipid nanocarriers improved oral absorption: in vitro characteristics and in vivo behavior in rats
文献类型：期刊论文
| 作者 | Zhang, Zhiwen1 ; Huang, Yan1,3; Gao, Fang1,2; Bu, Huihui1; Gu, Wangwen1; Li, Yaping1
|
| 刊名 | NANOSCALE
 |
| 出版日期 | 2011 |
| 卷号 | 3期号:4页码:1780-1787 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c0nr00879f |
| 文献子类 | Article |
| 英文摘要 | A nano-based delivery system was developed to improve the oral absorption of daidzein, which has poor hydrophilicity and lipophilicity. A daidzein-phospholipid complex (DPC) was firstly prepared to improve its lipophilicity, and then encapsulated into lipid nanocarriers (DLNs) to verify the effectiveness of the strategy in enhancing the oral delivery of daidzein. DLNs were spherical nanosized particles with evidently increased dissolution. DLNs were mainly distributed in stomach and proximal intestine of mice after oral administration, and the intestinal permeability of DLNs in rats was significantly improved when compared with that of daidzein solution. The peak concentration of daidzein in rats after oral administration of DPC and DLNs was 6833 +/- 1112 ng mL(-1) and 14 512 +/- 2390 ng mL(-1), respectively, which was improved over 10-fold and 21-fold than that of free daidzein. Moreover, the areas under the concentration-time curve (AUC(0-t)) of DPC and DLNs were enhanced by 3.62-fold and 6.87-fold compared with that of free daidzein. These results suggested that DLNs could be an effective strategy to improve the oral absorption of poor hydrophilic and lipophilic drugs like daidzein. |
| WOS关键词 | POORLY SOLUBLE DRUGS ; SOY ISOFLAVONES ; INTESTINAL-ABSORPTION ; DELIVERY-SYSTEM ; BREAST-CANCER ; BIOAVAILABILITY ; NANOPARTICLES ; GENISTEIN ; HUMANS ; FORMULATIONS |
| 资助项目 | National Basic Research Program of China[2009CB930304] ; National Basic Research Program of China[2007CB935800] ; National Natural Science Foundation of China[30925041] ; National Natural Science Foundation of China[30901866] ; Shanghai Nanomedicine Program[1052nm06300] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program''[2009ZX09501-024] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program''[2009ZX09301-001] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000289306900063 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278665]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 2.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China 3.Jiangsu Univ, Sch Pharm, Dept Pharmaceut, Zhenjiang 212013, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Zhiwen,Huang, Yan,Gao, Fang,et al. Daidzein-phospholipid complex loaded lipid nanocarriers improved oral absorption: in vitro characteristics and in vivo behavior in rats[J]. NANOSCALE,2011,3(4):1780-1787. |
| APA | Zhang, Zhiwen,Huang, Yan,Gao, Fang,Bu, Huihui,Gu, Wangwen,&Li, Yaping.(2011).Daidzein-phospholipid complex loaded lipid nanocarriers improved oral absorption: in vitro characteristics and in vivo behavior in rats.NANOSCALE,3(4),1780-1787. |
| MLA | Zhang, Zhiwen,et al."Daidzein-phospholipid complex loaded lipid nanocarriers improved oral absorption: in vitro characteristics and in vivo behavior in rats".NANOSCALE 3.4(2011):1780-1787. |
入库方式： OAI收割
来源：上海药物研究所
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