Co-administration of protein drugs with gold nanoparticles to enable percutaneous delivery
文献类型：期刊论文
| 作者 | Huang, Yongzhuo1,2 ; Yu, Faquan1; Park, Yoon-Shin1; Wang, Jianxin1; Shin, Meong-Cheol1; Chung, Hee Sun1; Yang, Victor C.1
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| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2010-12 |
| 卷号 | 31期号:34页码:9086-9091 |
| 关键词 | Drug delivery Percutaneous protein absorption Gold nanoparticle Co-delivery Transcutaneous immunization |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2010.08.046 |
| 文献子类 | Article |
| 英文摘要 | An interesting nanoscale interfacial phenomenon mediated by gold nanoparticles (Au-NPs) was found, in that co-administration with Au-NPs enables percutaneous delivery of protein drugs. The Au-NPs with a mean size of 5 nm were revealed to be skin permeable, presumably due to the nano-bio interaction with skin lipids and the consequent induction of transient and reversible openings on the stratum corneum. Importantly, when simultaneously applied with Au-NPs, the protein drugs were also granted the ability to penetrate the skin barrier and migrate into the deep layers. This indicated that co-administration with the skin-permeable Au-NPs could mediate proteins across the skin barrier. Such co-delivery effect highlights a simple yet effective method for overcoming the skin barrier for percutaneous protein drug delivery. Employing this method, a non-invasive vaccine delivery strategy was developed, and by topically co-administrating antigens with Au-NPs, robust immune responses were elicited in the tested animals. The results provide the promise for achieving a needleless and self-administrable transcutaneous vaccination. (C) 2010 Elsevier Ltd. All rights reserved. |
| WOS关键词 | TRANSCUTANEOUS IMMUNIZATION ; HAIR-FOLLICLES ; TRANSDERMAL DELIVERY ; SKIN ; PENETRATION ; VACCINATION ; MEMBRANES ; PATCH ; NANOTECHNOLOGY ; PERMEABILITY |
| 资助项目 | NIH[CA114612] ; NIH[NS066945] ; WCU project of South Korea[R31-2008-000-10103-01] ; Chinese Academy of Sciences[00000000] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000283814600030 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278700]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Yang, Victor C. |
| 作者单位 | 1.Univ Michigan, Coll Pharm, Ann Arbor, MI 48109 USA; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Yongzhuo,Yu, Faquan,Park, Yoon-Shin,et al. Co-administration of protein drugs with gold nanoparticles to enable percutaneous delivery[J]. BIOMATERIALS,2010,31(34):9086-9091. |
| APA | Huang, Yongzhuo.,Yu, Faquan.,Park, Yoon-Shin.,Wang, Jianxin.,Shin, Meong-Cheol.,...&Yang, Victor C..(2010).Co-administration of protein drugs with gold nanoparticles to enable percutaneous delivery.BIOMATERIALS,31(34),9086-9091. |
| MLA | Huang, Yongzhuo,et al."Co-administration of protein drugs with gold nanoparticles to enable percutaneous delivery".BIOMATERIALS 31.34(2010):9086-9091. |
入库方式： OAI收割
来源：上海药物研究所
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