Nanomicelle with long-term circulation and enhanced stability of camptothecin based on mPEGylated alpha,beta-poly (L-aspartic acid)-camptothecin conjugate
文献类型：期刊论文
| 作者 | Zhang, Weilu2; Huang, Jin2; Fan, Naiqian2; Yu, Jiahui2; Liu, Yongbiao1; Liu, Shiyuan4; Wang, Daxin5; Li, Yaping3
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| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
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| 出版日期 | 2010-11-01 |
| 卷号 | 81期号:1页码:297-303 |
| 关键词 | Camptothecin Click cycloaddition Polymeric nanomicelles Stability Long-term circulation |
| ISSN号 | 0927-7765 |
| DOI | 10.1016/j.colsurfb.2010.07.019 |
| 文献子类 | Article |
| 英文摘要 | To enhance the stability and long-term circulation of camptothecin (CPT), mPEGylated alpha,beta-poly (L-aspartic acid)-CPT conjugates were synthesized, and used to fabricate nanomicelle. Firstly, alpha,beta-poly (L-aspartic acid) derivative (PAA-der) containing alkyne groups was synthesized via the ring-opening of PSI with propargyl amine. And then, azide-functionalized CPT derivatives (CPT-N-3) and azide-terminated poly (ethylene glycol) methyl ether (mPEG-N-3) were conjugated with PAA-der by click cycloaddition to give mPEG-graft-PAA-CPT conjugates. The formation of mPEG-graft-PAA-CPT nanomicelles was confirmed by fluorescence spectrophotoscopy and particle size measurements. It was found that all the nanomicelles showed spherical shapes with size about 178 nm. MPEG-graft-PAA-CPT nanomicelles showed good storage stability, even incubation at 37 degrees C for 60 days, and improved the stability of CPT lactone form in aqueous media. A steady release rate of CPT was kept for 72 h, suggested the great potential of mPEG-graft-PAA-CPT nanomicelles as polymer prodrug of CPT. (C) 2010 Elsevier B.V. All rights reserved. |
| WOS关键词 | MICELLES ; DELIVERY ; ACID |
| 资助项目 | Natural Science Foundation of Jiangsu Province[BK2007245] ; Shanghai Municipality Commission for Special Project of Nanometer Science and Technology[0852nm03700] ; Shanghai Municipality Commission for Special Project of Nanometer Science and Technology[0952nm05300] ; Shanghai Municipality Commission for Non-governmental International Corporation Project[09540709000] ; International Corporation Project of Shanghai Municipality Commission[10410710000] ; Chinese Ministry of Science and Technology[2007CB936104] ; WUT[00000000] |
| WOS研究方向 | Biophysics ; Chemistry ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000281999000038 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278737]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Yu, Jiahui |
| 作者单位 | 1.Nanjing Med Univ, Affiliated Hosp 1, Dept Radiotherapy, Nanjing 210029, Peoples R China; 2.E China Normal Univ, Inst Adv Interdisciplinary Research, Shanghai 200062, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China 4.Changzheng Hosp, Dept Diagnost Imaging, Shanghai 200003, Peoples R China; 5.Yangzhou Univ, Subei Hosp Jiangsu Prov, Yangzhou 225001, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Weilu,Huang, Jin,Fan, Naiqian,et al. Nanomicelle with long-term circulation and enhanced stability of camptothecin based on mPEGylated alpha,beta-poly (L-aspartic acid)-camptothecin conjugate[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2010,81(1):297-303. |
| APA | Zhang, Weilu.,Huang, Jin.,Fan, Naiqian.,Yu, Jiahui.,Liu, Yongbiao.,...&Li, Yaping.(2010).Nanomicelle with long-term circulation and enhanced stability of camptothecin based on mPEGylated alpha,beta-poly (L-aspartic acid)-camptothecin conjugate.COLLOIDS AND SURFACES B-BIOINTERFACES,81(1),297-303. |
| MLA | Zhang, Weilu,et al."Nanomicelle with long-term circulation and enhanced stability of camptothecin based on mPEGylated alpha,beta-poly (L-aspartic acid)-camptothecin conjugate".COLLOIDS AND SURFACES B-BIOINTERFACES 81.1(2010):297-303. |
入库方式： OAI收割
来源：上海药物研究所
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