Pharmacokinetics in Rats and Efficacy in Murine Ovarian Cancer Model for Solid Lipid Nanoparticles Loading Docetaxel
文献类型：期刊论文
| 作者 | Zhang, Pengcheng ; Chen, Lingli; Zhang, Zhiwen; Lin, Liping; Li, Yaping
|
| 刊名 | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
 |
| 出版日期 | 2010-11 |
| 卷号 | 10期号:11页码:7541-7544 |
| 关键词 | Docetaxel Solid Lipid Nanoparticles Pharmacokinetics Anti-Tumor Efficacy Ovarian Carcinoma |
| ISSN号 | 1533-4880 |
| DOI | 10.1166/jnn.2010.2819 |
| 文献子类 | Article; Proceedings Paper |
| 英文摘要 | Docetaxel was used extensively in ovarian cancer treatment in the combination with platinum compound. However, the serious side effect of clinically available formulation limits its further application. The aim of this work was to evaluate the pharmacokinetic behavior, acute toxicity and in vivo antitumor efficacy in murine ovarian cancer model of docetaxel loaded solid lipid nanoparticles (DSN). The particle size of DSN was 97.4 +/- 6.4 nm, and the encapsulation efficiency and loading capacity were 91.1 +/- 1.5% and 3.52 +/- 0.05%, respectively. The release behavior of docetaxel from DSN showed that only 45% of docetaxel was released within 24 h. The pharmacokinetics and biodistribution showed that the half-life (t(1/2)) and mean residence time (MRT) of docetaxel in DSN treated rats were significantly elongated because of the redistribution of docetaxel from reticulo-endothelial system (RES) to circulation system. Compared with Taxotere (R), DSN showed more potent in vivo anti-ovarian cancer activity with higher maximum tolerated dose (MTD). Our results suggested for the first time that solid lipid nanoparticles could be a potential candidate to enhance the efficacy of anti-ovarian cancer of docetaxel with low toxicity. The systematical study on pharmacokinetics, biodistribution, in vivo anti-tumor activity and MTD of DSN could improve the understanding of increased antitumor activity of DSN in vivo. |
| WOS关键词 | IN-VIVO EVALUATION ; VITRO ; CYTOTOXICITY ; PACLITAXEL ; LIPOSOMES ; DRUGS |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000283621300127 |
| 出版者 | AMER SCIENTIFIC PUBLISHERS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278741]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Li, Yaping |
| 作者单位 | Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Pengcheng,Chen, Lingli,Zhang, Zhiwen,et al. Pharmacokinetics in Rats and Efficacy in Murine Ovarian Cancer Model for Solid Lipid Nanoparticles Loading Docetaxel[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(11):7541-7544. |
| APA | Zhang, Pengcheng,Chen, Lingli,Zhang, Zhiwen,Lin, Liping,&Li, Yaping.(2010).Pharmacokinetics in Rats and Efficacy in Murine Ovarian Cancer Model for Solid Lipid Nanoparticles Loading Docetaxel.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,10(11),7541-7544. |
| MLA | Zhang, Pengcheng,et al."Pharmacokinetics in Rats and Efficacy in Murine Ovarian Cancer Model for Solid Lipid Nanoparticles Loading Docetaxel".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 10.11(2010):7541-7544. |
入库方式： OAI收割
来源：上海药物研究所
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