One-step synthesis of amino-reserved chitosan-graft-polycaprolactone as a promising substance of biomaterial
文献类型：期刊论文
| 作者 | Duan, Kongrong1; Chen, Honglin1; Huang, Jin1; Yu, Jiahui1; Liu, Shiyuan2; Wang, Daxin3; Li, Yaping4
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| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2010-04-12 |
| 卷号 | 80期号:2页码:498-503 |
| 关键词 | Chitosan-graft-polycaprolactone One-step synthesis Biomaterials Methanesulfonic acid Brush-like polycations |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2009.12.013 |
| 文献子类 | Article |
| 英文摘要 | One-step approach was developed to synthesize amino-reserved chitosan-graft-polycaprolactone (CS-g-PCL) by grafting epsilon-CL oligomers onto the hydroxyl groups of CS via ring-opening polymerization by using methanesulfonic acid as solvent and catalyst. The controllable grafting content of PCL within CS-g-PCL provided the possibility to manipulate the biodegradation rate, hydrophilicity, and hence the cytotoxicity of CS-g-PCL. As a result, the specimen synthesized from the feed molar ratio of glucosamine units in CS vs. epsilon-CL as 1:12 showed equivalent cytotoxicity to the neat CS and PCL against KB cell line, and the cell viability was almost close to 100%. In addition, CS-g-PCL exhibited good solubility in organic solvents, facilitating formation of PCL/CS-g-PCL blend nanofibers via electrospinning with the use of DMF/CHCl3 as solvent. Owing to the enhanced cellular attachment results from cationic amino groups, it is promising that these copolymers are ideal substances for developing drug carriers and tissue engineering scaffolds. (C) 2009 Elsevier Ltd. All rights reserved. |
| WOS关键词 | MODIFIED GLYCOL CHITOSAN ; EPSILON-CAPROLACTONE ; ORGANIC CATALYST ; L-LACTIDE ; COPOLYMERS ; NANOPARTICLES ; MEMBRANE ; DELIVERY ; SCAFFOLD ; RELEASE |
| 资助项目 | Chinese Ministry of Science and Technology[2007CB936104] ; Chinese Ministry of Science and Technology[2009CB930300] ; Shanghai Municipality Commission for Special Project of Nanometer Science and Technology[0852nm03700] ; Shanghai Municipality Commission for Special Project of Nanometer Science and Technology[0952nm05300] ; Shanghai Municipality Commission for Non-governmental International Corporation Project[09540709000] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000276920500029 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278918]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Yu, Jiahui |
| 作者单位 | 1.E China Normal Univ, Inst Adv Interdisciplinary Res, Shanghai 200062, Peoples R China; 2.Changzheng Hosp, Dept Diagnost Imaging, Shanghai 200003, Peoples R China; 3.Yangzhou Univ, Subei Hosp Jiangsu Prov, Yangzhou 225001, Peoples R China; 4.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Duan, Kongrong,Chen, Honglin,Huang, Jin,et al. One-step synthesis of amino-reserved chitosan-graft-polycaprolactone as a promising substance of biomaterial[J]. CARBOHYDRATE POLYMERS,2010,80(2):498-503. |
| APA | Duan, Kongrong.,Chen, Honglin.,Huang, Jin.,Yu, Jiahui.,Liu, Shiyuan.,...&Li, Yaping.(2010).One-step synthesis of amino-reserved chitosan-graft-polycaprolactone as a promising substance of biomaterial.CARBOHYDRATE POLYMERS,80(2),498-503. |
| MLA | Duan, Kongrong,et al."One-step synthesis of amino-reserved chitosan-graft-polycaprolactone as a promising substance of biomaterial".CARBOHYDRATE POLYMERS 80.2(2010):498-503. |
入库方式： OAI收割
来源：上海药物研究所
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