Prostaglandin E-1 encapsulated into lipid nanoparticles improves its anti-inflammatory effect with low side-effect
文献类型：期刊论文
| 作者 | Gao, Yu; Xu, Pengfei; Chen, Lingli ; Li, Yaping
|
| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2010-03-15 |
| 卷号 | 387期号:1-2页码:263-271 |
| 关键词 | Prostaglandin E-1 Nanoparticles Anti-inflammation Allergenicity Irritation |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2009.12.019 |
| 文献子类 | Article |
| 英文摘要 | Prostaglandin E-1 (PGE1) shows various pharmacological activities including anti-inflammation. However, the rapid metabolization and inactivation of the intravenously administered PGE1 during the first passage through the lungs result in significant non-compliance in clinical trials which greatly limits its application. The aim of this work was to prepare the lipid nanoparticles loading PGE1 to improve its anti-inflammatory effect with low side-effect. The experimental results showed that PGE1 loaded lipid nanoparticles (PLNs) could be successfully prepared by high pressure homogenization with particle size 68.1 +/- 4.7 nm, zeta potential -3.32 +/- 0.37 mV and entrapment efficiency 92.1 +/- 1.3%. PLNs exhibited a sustained release with low burst drug release. PLNs could improve the inhibition effects of PGE1 on lipopolysaccharides (LPS)-induced TNF-alpha expression on macrophage RAW264.7 cells, and improve the inhibition of lymphocyte to endothelial cell adhesion and ICAM-1 adhesion molecule expression on HUVEC and MDA-MB-468 cell membrane. No allergenicity, vascular and muscle irritation were induced in animals by PLNs even at double of the highest drug concentration of clinical infusion. As a result, PLNs could be a more potential delivery system for PGE1 in the treatment of inflammation-related diseases. (C) 2009 Elsevier B.V. All rights reserved. |
| WOS关键词 | ADHESION MOLECULES ; INFLAMMATION ; SELECTIN ; PHARMACOKINETICS ; MICROSPHERES ; LIPO-PGE(1) ; ACTIVATION ; MECHANISMS ; DELIVERY ; DISEASES |
| 资助项目 | National Basic Research Program of China[2010CB934000] ; National Basic Research Program of China[2007CB935800] ; National Natural Science Foundation of China[30925041] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program, China"[2009ZX09501-024] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program, China"[2009ZX09301-001] ; Shanghai Nanomedicine Program[0852nm05700] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000275436800035 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278944]  |
| 专题 | 药物制剂研究中心 上海中药现代化研究中心 |
| 通讯作者 | Li, Yaping |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Yu,Xu, Pengfei,Chen, Lingli,et al. Prostaglandin E-1 encapsulated into lipid nanoparticles improves its anti-inflammatory effect with low side-effect[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2010,387(1-2):263-271. |
| APA | Gao, Yu,Xu, Pengfei,Chen, Lingli,&Li, Yaping.(2010).Prostaglandin E-1 encapsulated into lipid nanoparticles improves its anti-inflammatory effect with low side-effect.INTERNATIONAL JOURNAL OF PHARMACEUTICS,387(1-2),263-271. |
| MLA | Gao, Yu,et al."Prostaglandin E-1 encapsulated into lipid nanoparticles improves its anti-inflammatory effect with low side-effect".INTERNATIONAL JOURNAL OF PHARMACEUTICS 387.1-2(2010):263-271. |
入库方式： OAI收割
来源：上海药物研究所
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