中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 药物制剂研究中心
Fabrication of nanomicelle with enhanced solubility and stability of camptothecin based on alpha,beta-poly[(N-carboxybutyl)-L-aspartamide]-camptothecin conjugate

文献类型：期刊论文

作者Fan, Naiqian4; Duan, Kongrong4; Wang, Chengyun4; Liu, Shunying4; Luo, Shufang4; Yu, Jiahui4; Huang, Jin3,4; Li, Yaping1; Wang, Daxin2
刊名COLLOIDS AND SURFACES B-BIOINTERFACES
出版日期2010-02-01
卷号75期号:2页码:543-549
关键词alpha,beta-Poly[(N-carboxybutyl)-L-aspartamide] Camptothecin Nanomicelles Cytotoxicity Stability Solubility
ISSN号0927-7765
DOI10.1016/j.colsurfb.2009.09.034
文献子类Article
英文摘要This research is aimed to develop a nanomicelle delivery system in order to enhance the solubility and stability of camptothecin (CPT) in aqueous media. In this case, alpha,beta-poly[(N-carboxybutyl)-L-aspartamide] (PBAsp)-CPT was conjugated by the esterification between PBAsp and 20-OH of CPT, and hence used to fabricate nanomicelles with a particle size between the pore size of blood capillary in normal tissue and that in tumor tissue. It was worthy of note that the drug-loaded system of PBAsp-CPT nanomicelle improved the solubility and stability of CPT in aqueous media. However, with an increase of the CPT loading in PBAsp-CPT, the solubility sharply decreased. Meanwhile, the sizes of PBAsp-CPT nanomicelles showed a tendency of increase. Moreover, the drug release of PBAsp-CPT nanomicelles displayed a linear sustaining profile, and hence resulted in the essential decrease of cytotoxicity to L929 cell line. The assembled nanomicelles based on the PBAsp-CPT conjugates showed a great potential as polymer prodrug of tumor therapy, and the controlled nano-scale might achieve the passive tumor targeting. (C) 2009 Elsevier B.V. All rights reserved.
WOS关键词IN-VITRO CYTOTOXICITY ; ANTITUMOR-ACTIVITY ; ALBUMINS ; ANALOGS ; SERUM
资助项目National Natural Science Foundation of China[20504010] ; Chinese Ministry of Science and Technology[2007CB936104] ; Chinese Ministry of Science and Technology[2009CB930000] ; Chinese Ministry of Science and Technology[2009CB930300] ; Shanghai Municipality Commission for Special Project of Nanometer Science and Technology[0852nm03700] ; Shanghai Municipality Commission for Special Project of Nanometer Science and Technology[0952nm05300] ; Shanghai Municipality Commission for Non-governmental International Corporation Project[09540709000]
WOS研究方向Biophysics ; Chemistry ; Materials Science
语种英语
WOS记录号WOS:000276921900023
出版者ELSEVIER SCIENCE BV
源URL[http://119.78.100.183/handle/2S10ELR8/278980]  
专题药物制剂研究中心
通讯作者Yu, Jiahui
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China;
2.Yangzhou Univ, Subei Hosp Jiangsu Prov, Yangzhou 225001, Peoples R China
3.Wuhan Univ Technol, Coll Chem Engn, Wuhan 430070, Peoples R China;
4.E China Normal Univ, Inst Adv Interdisciplinary Res, Shanghai 200062, Peoples R China;
推荐引用方式
GB/T 7714		 Fan, Naiqian,Duan, Kongrong,Wang, Chengyun,et al. Fabrication of nanomicelle with enhanced solubility and stability of camptothecin based on alpha,beta-poly[(N-carboxybutyl)-L-aspartamide]-camptothecin conjugate[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2010,75(2):543-549.
APA Fan, Naiqian.,Duan, Kongrong.,Wang, Chengyun.,Liu, Shunying.,Luo, Shufang.,...&Wang, Daxin.(2010).Fabrication of nanomicelle with enhanced solubility and stability of camptothecin based on alpha,beta-poly[(N-carboxybutyl)-L-aspartamide]-camptothecin conjugate.COLLOIDS AND SURFACES B-BIOINTERFACES,75(2),543-549.
MLA Fan, Naiqian,et al."Fabrication of nanomicelle with enhanced solubility and stability of camptothecin based on alpha,beta-poly[(N-carboxybutyl)-L-aspartamide]-camptothecin conjugate".COLLOIDS AND SURFACES B-BIOINTERFACES 75.2(2010):543-549.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。