Quantitation of the tacrine analogue octahydroaminoacridine in human plasma by liquid chromatography-tandem mass spectrometry
文献类型：期刊论文
| 作者 | Han, Jiangbin2; Jiang, Shuang2; Cui, Xiangyong2; Sun, Yantong2,3; Li, Guoqing2; Zhang, Jiwen4 ; Fawcett, J. Paul1; Gu, Jingkai2
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| 刊名 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
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| 出版日期 | 2009-09-08 |
| 卷号 | 50期号:2页码:171-174 |
| 关键词 | Octahydroaminoacridine LC-MS/MS Quantitation Pharmacokinetics Plasma |
| ISSN号 | 0731-7085 |
| DOI | 10.1016/j.jpba.2009.03.022 |
| 文献子类 | Article |
| 英文摘要 | A rapid and sensitive method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed for the determination of octahydroaminoacridine in human plasma using tramadol as internal standard (I.S.). Sample preparation involved pH adjustment with sodium carbonate followed by solvent extraction with dichloromethane: ethyl ether (40:60, v/v). Chromatographic separation was achieved on a Venusil MP-C18 column (5 mu m, 100 mm x 4.6 mm) using acetonitrile: 10 MM ammonium acetate:formic acid (30:70:1, v/v/v) as mobile phase. Detection utilized an API 4000 system operated in the positive ion mode with multiple reaction monitoring of the analyte at m/z 203.1 -> 175.1 and of the I.S. at m/z 264.1 -> 58.0. The method was linear in the range 0.01-10ng/ml with a lower limit of quantitation of 0.01 ng/ml. Intra- and inter-day precisions measured as relative standard deviation were <3.15% and <5.01%, respectively. The method was successfully applied to a pharmacokinetic study involving oral administration of a tablet containing 4 mg octahydroaminoacricline succinate to healthy volunteers. Pharmacokinetic parameters for octahydroaminoacricline include C-max 1.19 +/- 0.53 ng/ml, T-max 0.77 +/- 0.17 h, AUC(0-t) 3.42 +/- 1.01 ng h/ml and t(1/2) 2.89 +/- 0.56 h. (C) 2009 Elsevier B.V. All rights reserved. |
| WOS关键词 | ALZHEIMERS-DISEASE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000267037700009 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279134]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Gu, Jingkai |
| 作者单位 | 1.Univ Otago, Sch Pharm, Dunedin, New Zealand 2.Jilin Univ, Res Ctr Drug Metab, Coll Life Sci, Changchun 130021, Peoples R China; 3.Jilin Univ, Sch Pharmaceut Sci, Changchun 130021, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Han, Jiangbin,Jiang, Shuang,Cui, Xiangyong,et al. Quantitation of the tacrine analogue octahydroaminoacridine in human plasma by liquid chromatography-tandem mass spectrometry[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2009,50(2):171-174. |
| APA | Han, Jiangbin.,Jiang, Shuang.,Cui, Xiangyong.,Sun, Yantong.,Li, Guoqing.,...&Gu, Jingkai.(2009).Quantitation of the tacrine analogue octahydroaminoacridine in human plasma by liquid chromatography-tandem mass spectrometry.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,50(2),171-174. |
| MLA | Han, Jiangbin,et al."Quantitation of the tacrine analogue octahydroaminoacridine in human plasma by liquid chromatography-tandem mass spectrometry".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 50.2(2009):171-174. |
入库方式： OAI收割
来源：上海药物研究所
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