Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: In vitro and in vivo results
文献类型：期刊论文
| 作者 | Gan, Li1,2; Gan, Yong1 ; Zhu, Chunliu1; Zhang, Xinxin1; Zhu, Jiabi2
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| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2009-01-05 |
| 卷号 | 365期号:1-2页码:143-149 |
| 关键词 | Cyclosporine A Microemulsion In situ gelling system Kelcogel (R) Ophthalmic delivery |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2008.08.004 |
| 文献子类 | Article |
| 英文摘要 | The objective of the present study was to design a novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of a lipophilic drug, cyclosporine A (CsA). A CsA-loaded microemulsion was prepared using castor oil, Solutol HS 15 (surfactant), glycerol and water. This microemulsion was then dispersed in a Kelcogel (R) solution to form the final microemulsion in situ electrolyte-triggered gelling system. In vitro, the viscosity of the CsA microemulsion Kelcogel (R) system increased dramatically on dilution with artificial tear fluid and exhibited pseudo-plastic rheology. In vivo results revealed that the AUC(0-->32h) of corneal CsA for the microemulsion Kelcogel (R) system was approximately three-fold greater than for a CsA emulsion. Moreover, at 32 h after administration, CsA concentrations delivered by the microemulsion Kelcogel (R) system remained at therapeutic levels in the cornea. This CsA microemulsion in situ electrolyte-triggered gelling system might provide an alternative approach to deliver prolonged precorneal residence time of CsA for preventing cornea allograft rejection. Published by Elsevier B.V. |
| WOS关键词 | OCULAR DRUG-DELIVERY ; GELLAN GUM ; EYE ; VEHICLES ; POLYMERS ; RABBITS ; CELLS ; PH |
| 资助项目 | National High Technology Research and Development Program of China[2007AA021604] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000262546700020 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279344]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Gan, Yong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gan, Li,Gan, Yong,Zhu, Chunliu,et al. Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: In vitro and in vivo results[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2009,365(1-2):143-149. |
| APA | Gan, Li,Gan, Yong,Zhu, Chunliu,Zhang, Xinxin,&Zhu, Jiabi.(2009).Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: In vitro and in vivo results.INTERNATIONAL JOURNAL OF PHARMACEUTICS,365(1-2),143-149. |
| MLA | Gan, Li,et al."Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: In vitro and in vivo results".INTERNATIONAL JOURNAL OF PHARMACEUTICS 365.1-2(2009):143-149. |
入库方式： OAI收割
来源：上海药物研究所
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