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Preparation of a Dispersible PEGylate Nanostructured Lipid Carriers (NLC) Loaded with 10-Hydroxycamptothecin by Spray-Drying

文献类型：期刊论文

作者Zhang, Xinxin1,2; Pan, Weisan1; Gan, Li2; Zhu, Chunliu2; Gan, Yong2; Nie, Shufang1
刊名CHEMICAL & PHARMACEUTICAL BULLETIN
出版日期2008-12
卷号56期号:12页码:1645-1650
关键词nanostructured lipid carrier 10-hydroxycamptothecin spray drying polyethylene glycol cellular uptake
ISSN号0009-2363
DOI10.1248/cpb.56.1645
文献子类Article
英文摘要Nanostructured lipid carriers (NLC) are based on mixture of solid lipids with spatially incompatible liquid lipids, which offer advantages of improving drug loading capacity and release properties. In the present study, hydroxycamptothecin (HCPT) loaded polyethylene glycol (PEG) modified NLC (PEG-NLC) was prepared by high pressure homogenize and spray drying method. PEG-NLC showed spherical particle with smooth surface in scanning electron microscopic (SEM) analysis. The crystallinity of lipid matrix within PEG-NLC was evaluated by powder X-ray diffraction and differential scanning calorimetry (DSC). The less ordered crystals or amorphous state of matrix were found in nanoparticles. A small, homogeneous particle size and high drug loading with fine entrapment efficiency of HCPT was obtained in PEG-NLC system. HCPT releasing from PEG-NLC showed a sustained release trend, and no significantly difference was found between two release curves of PEG-NLC before or after spray drying. After storage for 6 months, PEG-NLC powder after spray drying showed no significantly changes in particle size, drug loading and entrapment efficiency, crystal form and in vitro release. PEG modification statistically decreased the phagocytosis of NLC by RAW 264.7 cells, and spray drying process did not influence the cellular uptake of PEG-NLC. These results suggest that PEG-NLC prepared by spray drying is a stable and high-performance delivery system for HCPT.
WOS关键词PARTICLE-SIZE ; NANOPARTICLES
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:000261210100003
出版者PHARMACEUTICAL SOC JAPAN
源URL[http://119.78.100.183/handle/2S10ELR8/279414]  
专题药物制剂研究中心
通讯作者Pan, Weisan
作者单位1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Xinxin,Pan, Weisan,Gan, Li,et al. Preparation of a Dispersible PEGylate Nanostructured Lipid Carriers (NLC) Loaded with 10-Hydroxycamptothecin by Spray-Drying[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2008,56(12):1645-1650.
APA Zhang, Xinxin,Pan, Weisan,Gan, Li,Zhu, Chunliu,Gan, Yong,&Nie, Shufang.(2008).Preparation of a Dispersible PEGylate Nanostructured Lipid Carriers (NLC) Loaded with 10-Hydroxycamptothecin by Spray-Drying.CHEMICAL & PHARMACEUTICAL BULLETIN,56(12),1645-1650.
MLA Zhang, Xinxin,et al."Preparation of a Dispersible PEGylate Nanostructured Lipid Carriers (NLC) Loaded with 10-Hydroxycamptothecin by Spray-Drying".CHEMICAL & PHARMACEUTICAL BULLETIN 56.12(2008):1645-1650.

入库方式： OAI收割

来源：上海药物研究所

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