Cavities spatial distribution confined by microcrystalline cellulose particles determines tablet disintegration patterns
文献类型：期刊论文
| 作者 | Yin, Xianzhen1,5; Maharjan, Abi4,5; Fang, Longwei5; Wu, Li5; Zhang, Liu5; Shakya, Shailendra4,5; Qin, Wei5; Regmi, Balmukunda3; York, Peter1; Sun, Huimin2 |
| 刊名 | POWDER TECHNOLOGY
 |
| 出版日期 | 2018-11 |
| 卷号 | 339页码:717-727 |
| 关键词 | Disintegration patterns Microaystalline cellulose (MCC) tablet Synchrotron radiation X-ray microcomputed tomography (SR -mu CT) Principal component analysis (PCA) |
| ISSN号 | 0032-5910 |
| DOI | 10.1016/j.powtec.2018.08.060 |
| 文献子类 | Article |
| 英文摘要 | Cavities and the architectures inside tablet play a decisive role for the permeation of water within tablet to initiate disintegration phenomenon. The present study aims to establish inner structure characterization methodology based on synchrotron radiation X-ray microcomputed tomography (SR-mu CT) for microcrystalline cellulose (MCC) tablets and to correlate the cavities and 'their attributes to tablet disintegration phenomenon. The three-dimensional (3D) morphological architecture and quantitative data of single particles for 12 specifications of MCC, and respective MCC tablets' cavities structure were obtained through advanced SR-mu CT studies. The image processing techniques were established to study the morphology of voids and porosity in an axial and radial direction based on the highly resolved 3D structure of tablets. The in-situ visualization of morphological disintegration behavior indicates that there were two patterns of disintegrations, which can be cataloged as laminating type (LT) and splitting type (ST) disintegrations. The principal component analysis (PCA) was used for multivariate data analysis to get the meaningful correlation among disintegration behaviors, cavities morphology, single particles attributes, and the cavities spatial arrangement within the tablets. These findings have deepened insights into inner structures of tablets and single particle structural attributes to tablet disintegration, reflecting the mechanism of disintegration mode, and the significance of pharmaceutical structure evaluated via SR-mu CT. (C) 2018 Published by Elsevier B.V. |
| WOS关键词 | RAY COMPUTED MICROTOMOGRAPHY ; CONTROLLED-RELEASE KINETICS ; OSMOTIC PUMP TABLETS ; DRUG-RELEASE ; MICRO-CT ; POROSITY ; TOMOGRAPHY ; RADIATION ; MECHANISM ; MICROSTRUCTURE |
| 资助项目 | National Natural Science Foundation of China[81773645] ; National Science and Technology Major Project[2017ZX09101001-006] ; Research Foundation of the Shanghai Institute of Materia Medica[CASIMM0120163017] ; Youth Innovation Promotion Association CAS[2018323] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:000449892500068 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279512]  |
| 专题 | 药物制剂研究中心 分子影像中心（筹） |
| 通讯作者 | Sun, Huimin; Zhang, Jiwen |
| 作者单位 | 1.Univ Bradford, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England; 2.Natl Inst Food & Drug Control, Inst Control Packaging Mat & Pharmaceut Excipient, 2 Tiantan Xili, Beijing 100050, Peoples R China; 3.Tribhuvan Univ, Inst Med, Maharajgung Med Campus, Kathmandu, Nepal 4.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, 501 Haike Rd, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yin, Xianzhen,Maharjan, Abi,Fang, Longwei,et al. Cavities spatial distribution confined by microcrystalline cellulose particles determines tablet disintegration patterns[J]. POWDER TECHNOLOGY,2018,339:717-727. |
| APA | Yin, Xianzhen.,Maharjan, Abi.,Fang, Longwei.,Wu, Li.,Zhang, Liu.,...&Zhang, Jiwen.(2018).Cavities spatial distribution confined by microcrystalline cellulose particles determines tablet disintegration patterns.POWDER TECHNOLOGY,339,717-727. |
| MLA | Yin, Xianzhen,et al."Cavities spatial distribution confined by microcrystalline cellulose particles determines tablet disintegration patterns".POWDER TECHNOLOGY 339(2018):717-727. |
入库方式： OAI收割
来源：上海药物研究所
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