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Material distributions and functional structures in probiotic microcapsules

文献类型：期刊论文

作者Wu, Li1,2; Qin, Wei1,3; He, Yuanzhi1,3; Zhu, Weifeng3; Ren, Xiaohong1; York, Peter5; Xiao, Tiqiao4; Yin, Xianzhen1,5; Zhang, Jiwen1,2
刊名EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
出版日期2018-09-15
卷号122页码:1-8
关键词Probiotics Synchrotron radiation X-ray microcomputed tomography Microcapsules Structure Distribution
ISSN号0928-0987
DOI10.1016/j.ejps.2018.06.013
文献子类Article
英文摘要Smart microstructure design of dosage forms such as microcapsules that protect the microorganism, can improve probiotics survival from gastric pH challenges and prolong their shelf life. In this study, synchrotron radiation Xray microcomputed tomography (SR-mu CT) was applied to quantitatively reveal the material distributions and functional structures of bifidobacterium and lactobacillus microcapsules. The shell layer, middle protective layer, and the microorganisms as particles in the center layer were extracted and visualized. All the microorganisms were encapsulated by the shell completely, which prevents them from being destroyed by external environments. However, the non-uniform thickness of the shell and typical defects in the microcapsules were observed. The quantitative analysis and characterization of internal microstructures provide evidence of the need for further improvement in formulations and processing technologies for the structured system to deliver living microorganisms.
WOS关键词X-RAY MICROTOMOGRAPHY ; SIMULATED GASTROINTESTINAL CONDITIONS ; OSMOTIC PUMP TABLETS ; CONTROLLED-RELEASE ; VIABILITY ; PREVENTION ; RADIATION ; BIFIDOBACTERIA ; ENCAPSULATION ; MICROSPHERES
资助项目Shanghai Synchrotron Radiation Facility[00000000] ; Shanghai Institute of Applied Physics, Chinese Academy of Sciences[00000000] ; China Postdoctoral Science Foundation[2017M610284] ; Youth Innovation Promotion Association, CAS[2018323] ; National Natural Science Foundation of China[81573615] ; National Natural Science Foundation of China[81773645] ; National Science and Technology Major Project[2017ZX09101-001]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000439564000001
出版者ELSEVIER SCIENCE BV
源URL[http://119.78.100.183/handle/2S10ELR8/279579]  
专题药物制剂研究中心
分子影像中心（筹）
通讯作者Yin, Xianzhen; Zhang, Jiwen
作者单位1.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China;
2.Yantai Univ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Minist Educ, Yantai 264005, Peoples R China;
3.Jiangxi Univ Tradit Chinese Med, Minist Educ, Key Lab Modern Preparat TCM, Nanchang 330004, Jiangxi, Peoples R China;
4.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China
5.Univ Bradford, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England;
推荐引用方式
GB/T 7714		 Wu, Li,Qin, Wei,He, Yuanzhi,et al. Material distributions and functional structures in probiotic microcapsules[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2018,122:1-8.
APA Wu, Li.,Qin, Wei.,He, Yuanzhi.,Zhu, Weifeng.,Ren, Xiaohong.,...&Zhang, Jiwen.(2018).Material distributions and functional structures in probiotic microcapsules.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,122,1-8.
MLA Wu, Li,et al."Material distributions and functional structures in probiotic microcapsules".EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 122(2018):1-8.

入库方式： OAI收割

来源：上海药物研究所

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