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Identification of beagle food taking patterns and protocol for food effects evaluation on bioavailability

文献类型：期刊论文

作者Zhang, Guoqing3,4; Wang, Caifen3; Wu, Li1,3; Xu, Jian2,3; Hu, Xiaoxiao3; Shakya, Shailendra2,3; He, Yuanzhi3; Ren, Xiaohong3; Chen, Weidong4; Zhang, Jiwen2,3,4
刊名SCIENTIFIC REPORTS
出版日期2018-08-24
卷号8
ISSN号2045-2322
DOI10.1038/s41598-018-30937-1
文献子类Article
英文摘要Food is a known primary role to the exposure of the drugs orally administered. Since each animal may have unique food taking pattern and it is difficult to manipulate the food taking to animals, there lacks rationalized protocol for the food effects in pre-clinic study. The objective of this study was to identify the beagle food taking patterns and demonstrate their effects on bioavailability in valsartan. Herein, four types of food taking patterns of beagle were identified via inter-day and intra-day analysis, and named as Persisting, Pulsing, Postponing, Pushing ("4P Modes"), respectively, which were also validated by principal component analysis (PCA). Interestingly, food intake resulted in a reduced area under the concentration-time curve (AUC(0-12h)), maximum concentration (C-max) and absorption rate, whilst the reduction varied in "4P Modes" of food taking. General considerations in the design of experiment for food effect to the bioavailability in beagles have been established as: to recognize the food taking patterns in each animal, to confirm the inter-day stability of the food taking behaviors, to trace the food taking patterns in parallel with plasma sampling. In conclusion, the right animals with proper food taking patterns should be assessed and selected for pre-clinic bioavailability evaluations.
WOS关键词HIGH-FAT MEAL ; RELATIVE BIOAVAILABILITY ; ORAL BIOAVAILABILITY ; ANGIOTENSIN RECEPTOR ; DRUG-INTERACTIONS ; FED-STATE ; IN-VITRO ; PHARMACOKINETICS ; ABSORPTION ; DOGS
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050307] ; National Science and Technology Major Projects for the Major New Drugs Innovation and Development[2017ZX09101001-005] ; National Science and Technology Major Projects for the Major New Drugs Innovation and Development[2018ZX0921002-009] ; Research Foundation of the Shanghai Institute of Materia Medica[CASIMM0120163017]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000442606800011
出版者NATURE PUBLISHING GROUP
源URL[http://119.78.100.183/handle/2S10ELR8/279611]  
专题药物制剂研究中心
通讯作者Chen, Weidong; Zhang, Jiwen
作者单位1.Minist Educ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Yantai, Peoples R China;
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai, Peoples R China;
4.Anhui Univ Chinese Med, Inst Drug Metab, Sch Pharmaceut Sci, Hefei, Anhui, Peoples R China;
推荐引用方式
GB/T 7714		 Zhang, Guoqing,Wang, Caifen,Wu, Li,et al. Identification of beagle food taking patterns and protocol for food effects evaluation on bioavailability[J]. SCIENTIFIC REPORTS,2018,8.
APA Zhang, Guoqing.,Wang, Caifen.,Wu, Li.,Xu, Jian.,Hu, Xiaoxiao.,...&Zhang, Jiwen.(2018).Identification of beagle food taking patterns and protocol for food effects evaluation on bioavailability.SCIENTIFIC REPORTS,8.
MLA Zhang, Guoqing,et al."Identification of beagle food taking patterns and protocol for food effects evaluation on bioavailability".SCIENTIFIC REPORTS 8(2018).

入库方式： OAI收割

来源：上海药物研究所

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