Development and application of bio-sample quantification to evaluate stability and pharmacokinetics of inulin-type fructo-oligosaccharides from Morinda Officinalis
文献类型：期刊论文
| 作者 | Chi, Liandi1; Chen, Lingxiao1; Zhang, Jiwen2 ; Zhao, Jing1; Li, Shaoping1; Zheng, Ying1
|
| 刊名 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
 |
| 出版日期 | 2018-07-15 |
| 卷号 | 156页码:125-132 |
| ISSN号 | 0731-7085 |
| 关键词 | lnulin-type fructooligosaccharides (FOS) Morindo Officinalis Stability Absorption Bioavailability Gut microbiota |
| DOI | 10.1016/j.jpba.2018.04.028 |
| 文献子类 | Article |
| 英文摘要 | Inulin-type fructooligosaccharides (FOS) purified from Morinda Officinalis, with degrees of polymerization (DP) from 3 to 9, have been approved in China as an oral prescribed drug for mild and moderate depression episode, while the stability and oral absorption of this FOS mixtures are largely unknown. As the main active component and quality control marker for above FOS, DP5 was selected as the representative FOS in this study. Desalting method by ion exchange resin was developed to treat bio-sample, followed by separation and quantification by high performance liquid chromatography-charged aerosol detector. Results showed that the DP5 was stepwisely hydrolyzed in simulated gastric fluid and gut microbiota, while maintained stable in intestinal fluid. DP5 has poor permeability across Caco-2 monolayer with P-app of 5.22 x 10(-7) cm/s, and very poor oral absorption with bioavailability of (0.50 +/- 0.12)% in rat. In conclusion, FOS in Morinda Officinalis demonstrated poor chemical stability in simulated gastric fluid and human gut microbiota, and low oral absorption in rats. (C) 2018 Elsevier B.V. All rights reserved. |
| WOS关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY ; PLANTS ; MODEL |
| 资助项目 | Research Committee of University of Macau[MYRG2016-00090-ICMS-QRCM] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000435228400014 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279658]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Zheng, Ying |
| 作者单位 | 1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chi, Liandi,Chen, Lingxiao,Zhang, Jiwen,et al. Development and application of bio-sample quantification to evaluate stability and pharmacokinetics of inulin-type fructo-oligosaccharides from Morinda Officinalis[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2018,156:125-132. |
| APA | Chi, Liandi,Chen, Lingxiao,Zhang, Jiwen,Zhao, Jing,Li, Shaoping,&Zheng, Ying.(2018).Development and application of bio-sample quantification to evaluate stability and pharmacokinetics of inulin-type fructo-oligosaccharides from Morinda Officinalis.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,156,125-132. |
| MLA | Chi, Liandi,et al."Development and application of bio-sample quantification to evaluate stability and pharmacokinetics of inulin-type fructo-oligosaccharides from Morinda Officinalis".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 156(2018):125-132. |
入库方式： OAI收割
来源：上海药物研究所
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