Mechanistic investigation on the performance of Huperzine A loaded microparticles based on ultra-fine particle processing system
文献类型：期刊论文
| 作者 | Peng, Tingting4; Yang, Peipei4; Zhu, Chune3; Zhang, Xuejuan4; Wang, Xinyi4; Ran, Hao4; Bai, Xuequn4; Zhang, Jiwen2 ; Wu, Chuan-yu5; Pan, Xin1,4
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| 刊名 | POWDER TECHNOLOGY
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| 出版日期 | 2018-02-15 |
| 卷号 | 326页码:370-378 |
| ISSN号 | 0032-5910 |
| 关键词 | Microparticles (MPs) Additives Encapsulation efficiency Forming mechanism Compressibility |
| DOI | 10.1016/j.powtec.2017.11.063 |
| 文献子类 | Article |
| 英文摘要 | Ultra-fine particle processing system (UPPS) was more advantageous in producing microparticles (MPs) than the conventional technologies since it was applicable for a wide range of drugs and the MPs could be manufactured in a successive and controllable way under mild conditions. The MPs based on this technology showed small uniform particle size, proper surface roughness, and dense structure, which were anticipated to benefit tablet compaction. Therefore, ethyl cellulose (EC) was selected as the matrix material to confirm the superiorities of UPPS produced MPs for compaction due to its rigidity and inflexibility. To improve the encapsulation efficiency (EE%) of EC based MPs, hydrophilic/hydrophobic plasticizers and polymers were added, and the effect was mechanistically investigated regarding to the polymer properties and particle size of MPs. The results revealed that the EE% of MPs was significantly improved in the presence of hydrophilic polymers, which was mainly related to the reduced drug leakage as a result of modified polymer properties and decreased particle size of MPs. The forming mechanism of MPs determined by X-ray photoelectron spectroscopy (XPS) revealed that the MPs were enriched with low molecular weight polymers on the surface due to the unevenly migration driven by the centrifugal force. The topography of MPs determined by atomic force microscopy showed that the MPs had considerable rough surface to the commercial excipient, which benefited for further compaction. Consequently, the dissolution profile of MPs after compaction was approachable to that of original MPs and the tablets showed optimal content uniformity. (C) 2017 Elsevier B.V. All rights reserved. |
| WOS关键词 | DYNAMIC SURFACE-TENSION ; SPRAY-DRYING PROCESS ; HOT-MELT EXTRUSION ; DISINTEGRATING TABLET ; DIRECT COMPRESSION ; DRUG-RELEASE ; MICROSPHERES ; HYDROXYPROPYLMETHYLCELLULOSE ; DISPERSIONS ; TECHNOLOGY |
| 资助项目 | National High Technology Research and Development of the 863 Program[2014AA022205] ; Pearl River S&T Nova Program of Guangzhou[1317000297] ; International Scientific and Technological Cooperation Project of Nansha District[2015GJ003] ; Science and Technology Plan Projects of Guangdong Province[2015B020232010] ; Natural Science Fund Project of Guangdong Province[2016A030312013] ; Innovative Scientific Research Team Introducing Project of Zhongshan City[2015-224] ; China Postdoctoral Science Foundation[2016M602442] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000425077200040 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279901]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Zhu, Chune; Pan, Xin |
| 作者单位 | 1.Zhongshan WanYuan New Drug R&D Co Ltd, Zhongshan City 528451, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Guangdong Univ Technol, Inst Biomed & Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China; 4.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China; 5.Univ Surrey, Dept Chem & Proc Engn, Guildford GU2 7XH, Surrey, England; 6.Guangdong Res Ctr Drug Delivery Syst, Guangzhou 510006, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Tingting,Yang, Peipei,Zhu, Chune,et al. Mechanistic investigation on the performance of Huperzine A loaded microparticles based on ultra-fine particle processing system[J]. POWDER TECHNOLOGY,2018,326:370-378. |
| APA | Peng, Tingting.,Yang, Peipei.,Zhu, Chune.,Zhang, Xuejuan.,Wang, Xinyi.,...&Wu, Chuanbin.(2018).Mechanistic investigation on the performance of Huperzine A loaded microparticles based on ultra-fine particle processing system.POWDER TECHNOLOGY,326,370-378. |
| MLA | Peng, Tingting,et al."Mechanistic investigation on the performance of Huperzine A loaded microparticles based on ultra-fine particle processing system".POWDER TECHNOLOGY 326(2018):370-378. |
入库方式： OAI收割
来源：上海药物研究所
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