NIR-Triggered Release of Nitric Oxide with Upconversion Nanoparticles Inhibits Platelet Aggregation in Blood Samples
文献类型：期刊论文
| 作者 | Li, Chenxi1; Shen, Jianwei1; Yang, Jianfeng3; Yan, Jun1; Yu, Haijun2 ; Liu, Jian1
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| 刊名 | PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
 |
| 出版日期 | 2018-02 |
| 卷号 | 35期号:2 |
| 关键词 | gaseous signaling molecules NIR-triggered reaction nitric oxide release platelet aggregation upconversion nanoparticles |
| ISSN号 | 0934-0866 |
| DOI | 10.1002/ppsc.201700281 |
| 文献子类 | Article |
| 英文摘要 | There is a great challenge to overcome the limitation of tissue penetration depth, while maximizing the benefit of light-triggered biochemical cascades in a well-defined mode simultaneously. Here, a new method of near-infrared (NIR) light-triggered release of nitric oxide (NO) by developing upconversion nanoparticles (UCNPs)-based conjugate chemistry is reported. As the key nanotransducer in the design, core-shell-structured UCNPs are encapsulated with a layer of SiO2 and then covalently linked with a potent NO-releasing donor (S-nitroso-N-acetyl-dl-penicillamine, SNAP). It is featured with highly localized breakage of chemical bonds of SNAP molecules by NIR-UV upconversion, enabling simultaneous NO release in a light dosage-dependent manner. The biological effects of NO releasing are demonstrated by cellular imaging and inhibition of platelet aggregation from blood samples. This work provides a flexible and robust platform to generate cell-signaling gas molecules trigged by NIR laser with deep tissue penetration. |
| WOS关键词 | DEPENDENT PROTEIN-KINASE ; DRUG-DELIVERY ; IN-VIVO ; CARDIOVASCULAR-DISEASE ; PHOTODYNAMIC THERAPY ; TUMOR-THERAPY ; CANCER ; ACTIVATION ; PLATFORM ; CELLS |
| 资助项目 | Major State Basic Research Development Program[2013CB932702] ; National Natural Science Foundation of China[21275106] ; National Natural Science Foundation of China[21575095] ; Collaborative Innovation Center of Suzhou Nano Science and Technology[00000000] ; 111 project[00000000] ; Priority Academic Program Development of Jiangsu Higher Education Institutions[00000000] ; "1000 Youth Talents" plan of the Global Expert Recruitment Program[00000000] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000425641100001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279927]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Liu, Jian |
| 作者单位 | 1.Soochow Univ, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Soochow Univ, Cyrus Tang Hematol Ctr, Suzhou 215123, Jiangsu, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Chenxi,Shen, Jianwei,Yang, Jianfeng,et al. NIR-Triggered Release of Nitric Oxide with Upconversion Nanoparticles Inhibits Platelet Aggregation in Blood Samples[J]. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,2018,35(2). |
| APA | Li, Chenxi,Shen, Jianwei,Yang, Jianfeng,Yan, Jun,Yu, Haijun,&Liu, Jian.(2018).NIR-Triggered Release of Nitric Oxide with Upconversion Nanoparticles Inhibits Platelet Aggregation in Blood Samples.PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,35(2). |
| MLA | Li, Chenxi,et al."NIR-Triggered Release of Nitric Oxide with Upconversion Nanoparticles Inhibits Platelet Aggregation in Blood Samples".PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION 35.2(2018). |
入库方式： OAI收割
来源：上海药物研究所
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