Comparative in vivo constituents and pharmacokinetic study in rats after oral administration of ultrafine granular powder and traditional decoction slices of Chinese Salvia
文献类型：期刊论文
| 作者 | Zhi, Haijuan1; Li, Zhenwei1; Deng, Yanping1; Qi, Peng1; Hou, Jinjun1 ; Deng, Wen2; Cheng, Jinle2; Wu, Wanying1; Guo, Dean1
|
| 刊名 | Biomedical chromatography : BMC
 |
| 出版日期 | 2018-09-21 |
| 页码 | e4385 |
| ISSN号 | 1099-0801 |
| DOI | 10.1002/bmc.4385 |
| 文献子类 | Article |
| 英文摘要 | Salvia miltiorrhiza, one of the most well-known herbal medicines, is commonly used for the treatment of coronary heart diseases in China. Besides traditional decoction slices (TDS), another relatively new product of S. miltiorrhiza, ultrafine granular powder (UGP; D90 < 45 μm), is also increasingly being used. In this paper, a UHPLC-LTQ-Orbitrap MS technique was developed for a metabolite profile study after oral administration of UGP and TDS of S. miltiorrhiza. The results showed that the number of in vivo absorbed compounds from UGP was much greater than that from TDS, and different types of products from S. miltiorrhiza will have different metabolic processes in vivo. Furthermore, a UHPLC-Q-Trap MS/MS method for simultaneously determining four tanshinones (tanshinone IIA, dihydrotanshinone I, tanshinone I and cryptotanshinone) was established and applied to assess the pharmacokinetics of the two types of products. All of the analytes displayed significant higher area under the concentration-time curve and peak concentration after oral administration of UGP than after TDS, indicating that ultrafine powder product could improve the bioavailability and absorption of cryptotanshinon,tanshinone II A,dihydrotanshinonE I and tanshinone I in vivo. The present study provides scientific information for further exploration of the pharmacology of these two types of S. miltiorrhiza and offers a reference for clinical administration of S. miltiorrhiza. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266328]  |
| 专题 | 上海中药现代化研究中心 |
| 作者单位 | 1.Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China; 2.The Key Laboratory of Technology of Breaking Cell Wall and Application in Chinese Medicine Decoction Pieces, Zhongshan, China |
| 推荐引用方式 GB/T 7714 | Zhi, Haijuan,Li, Zhenwei,Deng, Yanping,et al. Comparative in vivo constituents and pharmacokinetic study in rats after oral administration of ultrafine granular powder and traditional decoction slices of Chinese Salvia[J]. Biomedical chromatography : BMC,2018:e4385. |
| APA | Zhi, Haijuan.,Li, Zhenwei.,Deng, Yanping.,Qi, Peng.,Hou, Jinjun.,...&Guo, Dean.(2018).Comparative in vivo constituents and pharmacokinetic study in rats after oral administration of ultrafine granular powder and traditional decoction slices of Chinese Salvia.Biomedical chromatography : BMC,e4385. |
| MLA | Zhi, Haijuan,et al."Comparative in vivo constituents and pharmacokinetic study in rats after oral administration of ultrafine granular powder and traditional decoction slices of Chinese Salvia".Biomedical chromatography : BMC (2018):e4385. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。