Advances in studies on fragmentation pathways of saponins in Anemarrhena asphodeloides
文献类型：期刊论文
| 作者 | Jia Yao2; Huang Jian2; Wu Bin1 |
| 刊名 | Journal of Shenyang Pharmaceutical University
 |
| 出版日期 | 2013 |
| 卷号 | 30期号:9页码:740-748 |
| 关键词 | Anemarrhena asphodeloides Bunge. spirostanol saponins furostanol saponins fragmentation pathways |
| ISSN号 | 1006-2858 |
| 其他题名 | 知母皂苷类化合物的质谱裂解规律研究进展 |
| 文献子类 | Review |
| 英文摘要 | Objective To summarize the fragmentation pathways of spirostanol saponins and furostanol saponins. Methods The chemical structures and the characteristic fragment ions of 46 saponins in Anemarrhena asphodeloides were reorganized. Results It was found that the spirostanol saponins firstly lose C-3 sugar moiety, and then the characteristic fragmentation involving the loss of 144 u or 114 u which arise from the cleavage of the E-ring is observed. The process results in the generation of m/z 255 or 285, m/z 253 or 283, m/z 251 or 281. When OH or OMe is substituted at C-22 position, the furostanol saponins usually yield [M+H-H_2O]~+ ions or [M+H-MeOH]~+ ions. Successively, the [M+H-H_2O]~+ ions or [M+H-MeOH]~+ ions generate product ions because of the loss of C-26 sugar moiety. The further fragmentation pathways are the same as the spirostanol saponins. Conclusion The fragmentation pathways and characteristic fragment ions will be helpful in identifying the structures of saponins in A. asphodeloides. |
| 资助项目 | 国家科技重大专项基金资助项目重大新药创制[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4945567 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267800]  |
| 专题 | 上海中药现代化研究中心 |
| 作者单位 | 1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 2.School of Chinese Traditional Materia Medica, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.; |
| 推荐引用方式 GB/T 7714 | Jia Yao,Huang Jian,Wu Bin. Advances in studies on fragmentation pathways of saponins in Anemarrhena asphodeloides[J]. Journal of Shenyang Pharmaceutical University,2013,30(9):740-748. |
| APA | Jia Yao,Huang Jian,&Wu Bin.(2013).Advances in studies on fragmentation pathways of saponins in Anemarrhena asphodeloides.Journal of Shenyang Pharmaceutical University,30(9),740-748. |
| MLA | Jia Yao,et al."Advances in studies on fragmentation pathways of saponins in Anemarrhena asphodeloides".Journal of Shenyang Pharmaceutical University 30.9(2013):740-748. |
入库方式： OAI收割
来源：上海药物研究所
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