Determination of Trimetazidine in Human Plasma by LC-MS/MS and Its Pharmacokinetic Study
文献类型：期刊论文
| 作者 | Lv Jiang1; Chen Xiaohui1; Zhang Ruirui1; Zhang Ming1; Zhang Hong1; Bi Kaishun2; Guo Dean3
|
| 刊名 | China Pharmacy
 |
| 出版日期 | 2011 |
| 卷号 | 22期号:2页码:143-145 |
| 关键词 | Trimetazidine LC-MS Pharmacokinetics Plasma concentration |
| ISSN号 | 1001-0408 |
| 其他题名 | LC-MS/MS法测定人血浆中曲美他嗪的浓度及其药动学研究 |
| 文献子类 | Article |
| 英文摘要 | OBJECTIVE: To establish an LC-MS/MS method for the determination of trimetazidine in human plasma and to study the pharmacokinetics of trimetazidine in healthy volunteers. METHODS: The determination was carried on a Shimadzu Shim-pack VP-ODS(150 mm*4.6 mm,5mum)column with mobile phase consisted of methanol-0.2%formic acid(12∶88)at a flow rate of 0.8 mL·min-1. Mass spectrum condition was electrospray ionization(ESI)and SIM mode selected ion mass spectral(m/z)267.25(trimetazidine,[M+H]+)and 338.05(famotidine,[M+H]+).RESULTS: The linear range of trimetazidine was 2~250 ng·mL-1 (r=0.997 8).The lower limit of quantification(LLOQ)for trimetazidine in plasma was 2 ng·mL-1.The RSD of intra-day and inter-day were lower than 9.3%.The extraction recovery was 71.1%~75.8%(RSD≤5.4%). Mean pharmacokinetic parameters of trimetazidine in 22 healthy volunteers after a single oral dose of trimetazidine tablets 40 mg were as follows:cmax(156.224.4)mug·L -1, tmax(2.160.36)h,t1/2(5.440.75)h,AUC0~24 (1 191205)mug·h·L-1,AUC0~(1 260212)mug·h·L-1. CONCLUSION: The method is simple, accurate, sensitive and specific for the determination and pharmacokinetic study of trimetazidine in human plasma. It is of significance to evaluate curative efficacy and safety of trimetazidine hydrochloride |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4121471 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267891]  |
| 专题 | 上海中药现代化研究中心 |
| 作者单位 | 1.School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.; 2.School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 201203, China.; 3.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 110016, China. |
| 推荐引用方式 GB/T 7714 | Lv Jiang,Chen Xiaohui,Zhang Ruirui,et al. Determination of Trimetazidine in Human Plasma by LC-MS/MS and Its Pharmacokinetic Study[J]. China Pharmacy,2011,22(2):143-145. |
| APA | Lv Jiang.,Chen Xiaohui.,Zhang Ruirui.,Zhang Ming.,Zhang Hong.,...&Guo Dean.(2011).Determination of Trimetazidine in Human Plasma by LC-MS/MS and Its Pharmacokinetic Study.China Pharmacy,22(2),143-145. |
| MLA | Lv Jiang,et al."Determination of Trimetazidine in Human Plasma by LC-MS/MS and Its Pharmacokinetic Study".China Pharmacy 22.2(2011):143-145. |
入库方式： OAI收割
来源：上海药物研究所
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