Pharmacokinetics of the Combination of Salvianolic Acids and Panax Notoginseng Saponins in Rat Plasma
文献类型：期刊论文
| 作者 | Yao Yan1; Chen Xiaohui1; Guo Dean2 ; Zhang Jinqiang1; Chen Xin2; Bi Kaishun1
|
| 刊名 | Chinese Pharmaceutical Journal
 |
| 出版日期 | 2010 |
| 卷号 | 45期号:15页码:1163-1167 |
| 关键词 | HPLC salvianolic acids panax notoginseng saponins pharmacokinetics |
| ISSN号 | 1001-2494 |
| 其他题名 | 丹参总酚酸与三七总皂苷合用4种丹酚酸成分在大鼠体内的药动学 |
| 文献子类 | Article |
| 英文摘要 | OBJECTIVE To determine four phenolic acids (procatechualdehyde, rosmarinic acid, lithospermic acid, salvianolic acid B) in rat plasma after oral administration of salvianolic acids and Panax notoginseng saponins (5:1), and to evaluate its pharmacokinetics. METHODS A high-performance liquid chromatography (HPLC) method was estahlished for the simultaneous determination of four phenolic acids. Chromatographic separation was achieved on a Zorbax SB-C_18 column (4.6 mm * 250 mm,5mum) at 30 ℃, with a linear gradient elution of acetonitrile and 0.026% aqueous phosphoricacid (v/v), at the flow rate of 1 mL. min_(-1). The eluent was detected at 280 nm for the four phenolic acids and internal standard. The plasma sample was extracted with ethyl acetate twice after acidification by 10% hydrochloric acid. The pharmacokinetic parameters were obtained. RESULTS The within-and between-day variation for the four phenolic acids in plasma were below 15% and the extraction recoverv was above 70%. The pharmacokinetic parameters for the four phenolic acids were as followes:t_(max), P_(max) and AUC_(0-) were 10.0 min,6.466 mg·L~(-1) and 82.1 mg·min·L~(-1) for procatechualdehyde; 11.7 min,10.50 mg·L~(-1) and 564.8 mg. min·L~(-1) for rosmarinic acid, respectively; 20.8min, 5.950 mg·L~(-1) and l 123 mg·min·L~(-1) for lithospermic acid respectively; 8.3 min,48.12 mg·L~(-1) and 4 026 mg·min·L~(-1) for salvianolic acid B. CONCLUSION The method is simple, rapid and sensitive for the determination of four compounds in rat plasma and the study of pharmacokinetics. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3919737 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267934]  |
| 专题 | 上海中药现代化研究中心 |
| 作者单位 | 1.College of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.; 2.Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Yao Yan,Chen Xiaohui,Guo Dean,et al. Pharmacokinetics of the Combination of Salvianolic Acids and Panax Notoginseng Saponins in Rat Plasma[J]. Chinese Pharmaceutical Journal,2010,45(15):1163-1167. |
| APA | Yao Yan,Chen Xiaohui,Guo Dean,Zhang Jinqiang,Chen Xin,&Bi Kaishun.(2010).Pharmacokinetics of the Combination of Salvianolic Acids and Panax Notoginseng Saponins in Rat Plasma.Chinese Pharmaceutical Journal,45(15),1163-1167. |
| MLA | Yao Yan,et al."Pharmacokinetics of the Combination of Salvianolic Acids and Panax Notoginseng Saponins in Rat Plasma".Chinese Pharmaceutical Journal 45.15(2010):1163-1167. |
入库方式： OAI收割
来源：上海药物研究所
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