Metabolic study of ginsenoside Re in rats
文献类型：期刊论文
| 作者 | CHEN Guangtong2; YANG Min1; GUO Dean1
|
| 刊名 | China Journal of Chinese Materia Medica
 |
| 出版日期 | 2009 |
| 卷号 | 34期号:12页码:1540-1543 |
| 关键词 | LC-MS/MS ginsenoside Re metabolism LC-MS/MS |
| ISSN号 | 1001-5302 |
| 其他题名 | 人参皂苷Re在大鼠体内的代谢研究 |
| 文献子类 | Article |
| 英文摘要 | Objective:To systemically study the metabolism of ginsenoside Re in rats. Method: Six SD rats were used divided into 3 groups. After oral administration of ginsenoside Re at a dosage of 100 mg ·kg~(-1),feces were collected at 12, 24, 36, 48, and 60 h. The microbial transformation metabolites of ginsenoside Re were used as standard references. HPLC-ESI-MS/MS analysis was used in the metabolism studies. Result: Six metabolites of ginsenoside Re were detected in rat feces by HPLC-ESI-MS/MS analysis. Their structures were identified as 20(S)-ginsenoside Rg_2,20(S)-ginsenoside Rh_1,20(R)-ginsenoside Rh_1,ginsenoside F_1,3-oxo-ginsenoside Rh_1, and protopanaxatriol. Conclusion: Ginsenoside Re has the same metabolic pathway with microorganisms, to some extent, justified the use of microbial models for mammalian metabolism studies. |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3759233 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267974]  |
| 专题 | 上海中药现代化研究中心 |
| 作者单位 | 1.Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 2.Medical College, Nantong University, Nantong, Jiangsu 226001, China.; |
| 推荐引用方式 GB/T 7714 | CHEN Guangtong,YANG Min,GUO Dean. Metabolic study of ginsenoside Re in rats[J]. China Journal of Chinese Materia Medica,2009,34(12):1540-1543. |
| APA | CHEN Guangtong,YANG Min,&GUO Dean.(2009).Metabolic study of ginsenoside Re in rats.China Journal of Chinese Materia Medica,34(12),1540-1543. |
| MLA | CHEN Guangtong,et al."Metabolic study of ginsenoside Re in rats".China Journal of Chinese Materia Medica 34.12(2009):1540-1543. |
入库方式： OAI收割
来源：上海药物研究所
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