Drug discovery based on classic natural products
文献类型：期刊论文
| 作者 | HU Li-hong; XU Ji-qing |
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2009 |
| 卷号 | 44期号:1页码:11-18 |
| 关键词 | drug discovery classic natural product molecular mechanism of action structure-activity relationship study resource study |
| ISSN号 | 0513-4870 |
| 其他题名 | 基于经典天然产物的药物发现研究 |
| 文献子类 | Review |
| 英文摘要 | We think the strategy of classic natural product-based drug discovery will be an effective way for us to develop new drugs with independent intellectual property. The strategy includes: to study the molecular mechanism of action of classic natural product with chemical genetics and chemical biology approaches firstly; then establish the proper in vitro bioassay or bioassay system based on its molecular mechanism for their pharmacodynamic evaluation; finally, study their structure-activity, structure-toxicity and structure-ADME properties with medicinal chemistry. |
| 资助项目 | 国家自然科学基金[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3553873 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268023]  |
| 专题 | 上海中药现代化研究中心 |
| 作者单位 | Shanghai Research Center for Modernization of Traditional Chinese Medicine,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | HU Li-hong,XU Ji-qing. Drug discovery based on classic natural products[J]. Acta Pharmaceutica Sinica,2009,44(1):11-18. |
| APA | HU Li-hong,&XU Ji-qing.(2009).Drug discovery based on classic natural products.Acta Pharmaceutica Sinica,44(1),11-18. |
| MLA | HU Li-hong,et al."Drug discovery based on classic natural products".Acta Pharmaceutica Sinica 44.1(2009):11-18. |
入库方式： OAI收割
来源：上海药物研究所
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