Anti-proliferation activity of terpenoids isolated from Euphorbia kansui in human cancer cells and their structure-activity relationship
文献类型：期刊论文
| 作者 | Hou Jin-Jun ; Shen Yao; Yang Zhou; Fang Lin; Cai Lu-Ying; Yao Shuai; Long Hua-Li; Wu Wan-Ying; Guo De-An
|
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2017-10 |
| 卷号 | 15期号:10页码:766-774 |
| 关键词 | Terpenoids Anti-proliferation activity Human cancer cells Structure-activity relationship |
| ISSN号 | 2095-6975 |
| 文献子类 | Article |
| 英文摘要 | Euphorbia kansui is a commonly used traditional Chinese medicine for the treatment of edema, pleural effusion, and asthma, etc. According to the previous researches, terpenoids in E. kansui possess various biological activities, e.g., anti-virus, anti-allergy, antitumor effects. In this work, twenty five terpenoids were isolated from E. kansui, including thirteen ingenane- and eight jatrophane-type diterpenoids (with two new compounds, kansuinin P and Q) and four triterpenoids. Eighteen of them were analyzed by MTS assay for in vitro anticancer activity in five human cancer cell lines. Structure-activity relationship for 12 ingenane-type diterpenoids in colorectal cancer Colo205 cells were preliminary studied. Significant anti-proliferation activities were observed in human melanoma cells breast cancer MDA-MB-435 cells and Colo205 cells. More than half of the isolated ingenane-type diterpenoids showed inhibitory activities in MDA-MB-435 cells. Eight ingenane-and one jatrophane-type diterpenoids possessed much lower IC50 values in MDA-MB-435 cells than positive control staurosporine. Preliminary structure-activity relationship analysis showed that substituent on position 20 was important for the activity of ingenane-type diterpenoids in Colo205 cells and substituent on position 3 contributed more significant biological activity of the compounds than that on position 5 in both MDA-MB-435 and Colo205 cells. |
| WOS关键词 | ROOTS ; DITERPENES ; DIVISION ; XENOPUS ; ESTERS |
| 资助项目 | National Natural Science Foundation of China[81073026] |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6099365 |
| WOS记录号 | WOS:000416074700006 |
| 出版者 | CHINESE JOURNAL NATURAL MEDICINES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272460]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Wu Wan-Ying; Guo De-An |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, Shanghai Res Ctr Modernizat Tradit Chinese Med, Haike Rd 501, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hou Jin-Jun,Shen Yao,Yang Zhou,et al. Anti-proliferation activity of terpenoids isolated from Euphorbia kansui in human cancer cells and their structure-activity relationship[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2017,15(10):766-774. |
| APA | Hou Jin-Jun.,Shen Yao.,Yang Zhou.,Fang Lin.,Cai Lu-Ying.,...&Guo De-An.(2017).Anti-proliferation activity of terpenoids isolated from Euphorbia kansui in human cancer cells and their structure-activity relationship.CHINESE JOURNAL OF NATURAL MEDICINES,15(10),766-774. |
| MLA | Hou Jin-Jun,et al."Anti-proliferation activity of terpenoids isolated from Euphorbia kansui in human cancer cells and their structure-activity relationship".CHINESE JOURNAL OF NATURAL MEDICINES 15.10(2017):766-774. |
入库方式： OAI收割
来源：上海药物研究所
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