New depsides from the roots of Salvia miltiorrhiza and their radical scavenging capacity and protective effects against H2O2-induced H9c2 cells
文献类型：期刊论文
| 作者 | Zhang, Jianqing1,2; Jin, Qinghao2; Deng, Yanping2; Hou, Jinjun2 ; Wu, Wanying2; Guo, Dean1,2
|
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2017-09 |
| 卷号 | 121页码:46-52 |
| 关键词 | Salvia miltiorrhiza Depsides Radical-scavenging Protective effect H9c2 cells |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2017.06.018 |
| 文献子类 | Article |
| 英文摘要 | Phytochemical investigation of the roots of Salvia miltiorrhiza led to isolations of two new depsides (1-2), along with thirteen known compounds (3-15). Their structures and relative stereochemistry were elucidated by NMR spectral (H-1 and C-13 NMR, HSQC, HMBC), CD and HR-ESIMS data analyses. The absolute configuration of 1 was determined by comparison of the experimental and calculated ECD spectra. All the depsides (1 10) were found to exhibit stronger free radical scavenging capacity (ranging from 2.62 to 22.05 mu M) than diterpenoids (11-15, IC50 > 100 mu M), among which Salvianolic acid A and Salvianolic acid B were the most potent compounds. Additionally, most of depsides (1, 3, 5, 7, 8, 9, 10) possessed significant protective effects against H2O2-induced H9c2 apoptosis in low concentrations. The negative mode collision-induced dissociations of compound 1 and 2 were featured by the alpha-cleavage and beta-cleavage to lose danshensu (198 Da) and caffeic acid (180 Da), respectively, while a,13-dihydroxybenzenes depsides (8-hydroxy) showed characteristic neutral elimination of H20. |
| WOS关键词 | DIODE-ARRAY DETECTION ; ACID-B ; LIQUID-CHROMATOGRAPHY ; DITERPENOID CONSTITUENTS ; MASS-SPECTROMETRY ; DANSHEN ; IDENTIFICATION ; CHEMISTRY |
| 资助项目 | National Natural Science Foundation of China[81530095] ; Shanghai Municipal Science and Technology Commission[15DZ0502800] ; National Standardization Program for Chinese Medicine[ZYBZH-C-SH-49] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000411543900006 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272501]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Wu, Wanying; Guo, Dean |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Haike Rd 501, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jianqing,Jin, Qinghao,Deng, Yanping,et al. New depsides from the roots of Salvia miltiorrhiza and their radical scavenging capacity and protective effects against H2O2-induced H9c2 cells[J]. FITOTERAPIA,2017,121:46-52. |
| APA | Zhang, Jianqing,Jin, Qinghao,Deng, Yanping,Hou, Jinjun,Wu, Wanying,&Guo, Dean.(2017).New depsides from the roots of Salvia miltiorrhiza and their radical scavenging capacity and protective effects against H2O2-induced H9c2 cells.FITOTERAPIA,121,46-52. |
| MLA | Zhang, Jianqing,et al."New depsides from the roots of Salvia miltiorrhiza and their radical scavenging capacity and protective effects against H2O2-induced H9c2 cells".FITOTERAPIA 121(2017):46-52. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。