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Approaches to establish Q-markers for the quality standards of traditional Chinese medicines
文献类型：期刊论文
| 作者 | Yang, Wenzhi1; Zhang, Yibei1; Wu, Wanying1 ; Huang, Luqi3; Guo, Dean1; Liu, Changxiao2
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| 刊名 | ACTA PHARMACEUTICA SINICA B
 |
| 出版日期 | 2017-07 |
| 卷号 | 7期号:4页码:439-446 |
| 关键词 | Traditional Chinese medicine Q-marker Quality control Property-effect-component |
| ISSN号 | 2211-3835 |
| DOI | 10.1016/j.apsh.2017.04.012 |
| 文献子类 | Review |
| 英文摘要 | Traditional Chinese medicine (TCM) has played a pivotal role in maintaining the health of Chinese people and is now gaining increasing acceptance around the global scope. However, TCM is confronting more and more concerns with respect to its quality. The intrinsic "multicomponent and multitarget" feature of TCM necessitates the establishment of a unique quality and bioactivity evaluation system, which is different from that of the Western medicine. However, TCM is investigated essentially as "herbal medicine" or "natural product", and the pharmacopoeia quality monographs are actually chemical markers -based, which can ensure the consistency only in the assigned chemical markers, but, to some extent, have deviated from the basic TCM theory. A concept of "quality marker" (Q-marker), following the "property-effect-component" theory, is proposed. The establishment of Q-marker integrates multidisciplinary technologies like natural products chemistry, analytical chemistry, bionics, chemometrics, pharmacology, systems biology, and pharmacodynamics, etc. Q-marker-based fingerprint and multi component determination conduce to the construction of more scientific quality control system of TCM. This review delineates the background, definition, and properties of Q-marker, and the associated technologies applied for its establishment. Strategies and approaches for establishing Q-marker-based TCM quality control system are presented and highlighted with a few TCM examples. (C) 2017 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND. |
| WOS关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY ; PANAX-GINSENG ; XUESHUANTONG INJECTION ; METABOLOMICS APPROACH ; EFFICIENT DISCOVERY ; BIOACTIVE COMPOUNDS ; GANODERMA-LUCIDUM ; MASS-SPECTROMETRY ; NATURAL COMPOUNDS ; PATENT MEDICINES |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6048293 |
| WOS记录号 | WOS:000417190000004 |
| 出版者 | INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272572]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Guo, Dean; Liu, Changxiao |
| 作者单位 | 1.Shanghai Inst Mat Med, Natl Engn Lab Standardizat Tradit Chinese Med, Shanghai 201203, Peoples R China; 2.Tainjin Inst Pharm Res, Res Ctr New Drug Evaluat, Tianjin 300193, Peoples R China 3.Chinese Acad Chinese Med Sci, Res Ctr Chinese Med Resources, Beijing 100700, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yang, Wenzhi,Zhang, Yibei,Wu, Wanying,et al. Approaches to establish Q-markers for the quality standards of traditional Chinese medicines[J]. ACTA PHARMACEUTICA SINICA B,2017,7(4):439-446. |
| APA | Yang, Wenzhi,Zhang, Yibei,Wu, Wanying,Huang, Luqi,Guo, Dean,&Liu, Changxiao.(2017).Approaches to establish Q-markers for the quality standards of traditional Chinese medicines.ACTA PHARMACEUTICA SINICA B,7(4),439-446. |
| MLA | Yang, Wenzhi,et al."Approaches to establish Q-markers for the quality standards of traditional Chinese medicines".ACTA PHARMACEUTICA SINICA B 7.4(2017):439-446. |
入库方式： OAI收割
来源：上海药物研究所
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