A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives under Pd(OAc)(2)/HCOOH system
文献类型：期刊论文
| 作者 | Zhou, Yang3; Chen, Ping3; Lv, Xue1; Niu, Junxing1; Wang, Yingying1; Lei, Min1 ; Hu, Lihong1,2
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| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2017-06-07 |
| 卷号 | 58期号:23页码:2232-2235 |
| 关键词 | 2-Formylbenzoic acid Isoindolin-1-one Pd(OAc)(2) Hydrogenation Cyclization |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2017.04.073 |
| 文献子类 | Article |
| 英文摘要 | A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives from 2-formylbenzoic acid and amine under Pd(OAc)(2)/HCOOH system has been described. The whole process is carried out in ligand-free conditions and furnished the desired products by reductive intramolecular cyclization. Furthermore, this procedure is applied successfully for the modification of natural products, such as vindoline and estrone. (C) 2017 Elsevier Ltd. All rights reserved. |
| WOS关键词 | TNF-ALPHA PRODUCTION ; TRANSFER HYDROGENATION ; REDUCTIVE AMINATION ; FORMIC-ACID ; WATER ; CATALYST ; AMINES ; INHIBITORS ; ALKALOIDS ; SOLVENT |
| 资助项目 | National Natural Science Foundation of China, China[81473110] ; Special Fund for Strategic Pilot Technology Chinese Academy of Sciences[XDA12040303] ; Shanghai Science & Technology Support Program[13431900401] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000402355400014 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272616]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Lei, Min; Hu, Lihong |
| 作者单位 | 1.Univ Chinese Acad Sci, Shanghai Inst Mat Medica, Chinese Acad Sci, Shanghai, Peoples R China; 2.Nanjing Univ Chinese Med, Jiangsu Key Lab Funct Substance Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Stake Key Lab Cultivat Base TCM Qual & Efficacy,S, Nanjing, Jiangsu, Peoples R China 3.Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhou, Yang,Chen, Ping,Lv, Xue,et al. A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives under Pd(OAc)(2)/HCOOH system[J]. TETRAHEDRON LETTERS,2017,58(23):2232-2235. |
| APA | Zhou, Yang.,Chen, Ping.,Lv, Xue.,Niu, Junxing.,Wang, Yingying.,...&Hu, Lihong.(2017).A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives under Pd(OAc)(2)/HCOOH system.TETRAHEDRON LETTERS,58(23),2232-2235. |
| MLA | Zhou, Yang,et al."A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives under Pd(OAc)(2)/HCOOH system".TETRAHEDRON LETTERS 58.23(2017):2232-2235. |
入库方式： OAI收割
来源：上海药物研究所
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