Effects of Chinese herbal medicine Xiangbin prescription on gastrointestinal motility
文献类型：期刊论文
| 作者 | Jiang, Zhi1; Cao, Li-Xing1; Liu, Bo1; Chen, Qi-Cheng1; Shang, Wen-Fan1; Zhou, Lu3; Li, Dan-Yan1; Guo, De-An2 ; Chen, Zhi-Qiang1
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| 刊名 | WORLD JOURNAL OF GASTROENTEROLOGY
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| 出版日期 | 2017-04-28 |
| 卷号 | 23期号:16页码:2987-2994 |
| 关键词 | Antrotroduodenojejunal manometry Gastrointestinal motility Migrating motor complex Xiangbin concoction Motilin Ghrelin |
| ISSN号 | 1007-9327 |
| DOI | 10.3748/wjg.v23.i16.2987 |
| 文献子类 | Article |
| 英文摘要 | AIM To investigate the effects of Xiangbin prescription (XBP), a Chinese herbal concoction, on gastrointestinal motility. METHODS Forty healthy volunteers were recruited for this randomized controlled trial of XBP. Antroduodenojejunal manometry was used to monitor gastrointestinal motility in these subjects. After the subjects had fasted for at least 12 h, XBP (n = 30) or placebo (n = 10) was orally administrated and gastrointestinal motility was recorded for 4 h. Plasma motilin and ghrelin were measured by enzyme-linked immunosorbent assay. RESULTS Oral administration of XBP significantly increased the amplitude of duodenal contractions [19.5 (13.0-26.7) vs 16.9 (12.3-23.9), P < 0.05], jejunal contractions [18.3 (15.3-25.0) vs 15.4 (11.7-23.9), P < 0.01], and the motility index of duodenal contractions [522.0 (146.0-139.0) vs 281.0 (76.5-1006.0), P < 0.01] in phase. of the migratory motor complex (MMC), which subsequently initiated the MMC cycle [74.0 (30.0-118.0) vs 116.5 (24.0-219.0), P < 0.05], shortened the duration of phase I of the MMC [42.0 (0.0-90.0) vs 111.5 (42.0-171.0), P < 0.01], and lengthened the duration of phase. of the MMC [120 (21-240) vs 58 (16-170), P < 0.01] compared to the duration before XBP administration. There were significant differences in the amplitude of jejunal contractions [19.8 (14.0-30.0) vs 18.0 (13.0-28.5), P < 0.05], the motility index of duodenal contractions [236.0 (115.0-306.0) vs 195.0 (109.0-310.0), P < 0.05)], and jejunal contractions [214.0 (95.0-403.0) vs 178.0(55.0-304.0), P < 0.01] in phase. of the MMC. Oral administration of XBP greatly increased plasma motilin (57.69 +/- 9.03 vs 49.38 +/- 8.63, P < 0.01) and ghrelin (279.20 +/- 104.31 vs 238.73 +/- 115.59, P < 0.01) concentrations compared to concentrations after oral administration of the placebo. CONCLUSION XBP can stimulate duodenal and jejunal motility and increase the concentrations of plasma motilin and ghrelin. The clinical applicability of XBP in treating GDIM deserves investigation. |
| WOS关键词 | MIGRATING MOTOR COMPLEX ; MECHANISM ; RECEPTOR ; GHRELIN ; CONTRACTILITY ; STOMACH ; ARECA ; RATS ; NUT |
| 资助项目 | Guangdong Provincial Department of Science and Technology[[2013] |
| WOS研究方向 | Gastroenterology & Hepatology |
| 语种 | 英语 |
| WOS记录号 | WOS:000400580900018 |
| 出版者 | BAISHIDENG PUBLISHING GROUP INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272690]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Chen, Zhi-Qiang |
| 作者单位 | 1.Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou 510120, Guangdong, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China 3.Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100005, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Jiang, Zhi,Cao, Li-Xing,Liu, Bo,et al. Effects of Chinese herbal medicine Xiangbin prescription on gastrointestinal motility[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2017,23(16):2987-2994. |
| APA | Jiang, Zhi.,Cao, Li-Xing.,Liu, Bo.,Chen, Qi-Cheng.,Shang, Wen-Fan.,...&Chen, Zhi-Qiang.(2017).Effects of Chinese herbal medicine Xiangbin prescription on gastrointestinal motility.WORLD JOURNAL OF GASTROENTEROLOGY,23(16),2987-2994. |
| MLA | Jiang, Zhi,et al."Effects of Chinese herbal medicine Xiangbin prescription on gastrointestinal motility".WORLD JOURNAL OF GASTROENTEROLOGY 23.16(2017):2987-2994. |
入库方式： OAI收割
来源：上海药物研究所
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