A feasible, economical, and accurate analytical method for simultaneous determination of six alkaloid markers in Aconiti Lateralis Radix Praeparata from different manufacturing sources and processing ways
文献类型：期刊论文
| 作者 | Zhang Yi-Bei; Da Juan; Zhang Jing-Xian; Li Shang-Rong; Chen Xin; Long Hua-Li; Wang Qiu-Rong; Cai Lu-Ying; Yao Shuai; Hou Jin-Jun
|
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2017-04 |
| 卷号 | 15期号:4页码:301-309 |
| 关键词 | Aconiti Lateralis Radix Praeparata Single Standard for Determination of Multi-Components (SSDMC) Monoester-diterpenoidaconitines (MDAs) Diester-diterpenoidaconitines (DDAs) |
| ISSN号 | 2095-6975 |
| DOI | 10.1016/S1875-5364(17)30048-1 |
| 文献子类 | Article |
| 英文摘要 | Aconiti Lateralis Radix Praeparata (Fuzi) is a commonly used traditional Chinese medicine in clinic for its potency in restoring yang and rescuing from collapse. Aconiti alkaloids, mainly including monoester-diterpenoidaconitines (MDAs) and diester-diterpenoidaconitines (DDAs), are considered to act as both bioactive and toxic constituents. In the present study, a feasible, economical, and accurate HPLC method for simultaneous determination of six alkaloid markers using the Single Standard for Determination of Multi-Components (SSDMC) method was developed and fully validated. Benzoylmesaconine was used as the unique reference standard. This method was proven as accurate (recovery varying between 97.5%-101.8%, RSD < 3%), precise (RSD 0.63%-2.05%), and linear (R > 0.999 9) over the concentration ranges, and subsequently applied to quantitative evaluation of 62 batches of samples, among which 45 batches were from good manufacturing practice (GMP) facilities and 17 batches from the drug market. The contents were then analyzed by principal component analysis (PCA) and homogeneity test. The present study provided valuable information for improving the quality standard of Aconiti Lateralis Radix Praeparata. The developed method also has the potential in analysis of other Aconitum species, such as Aconitum carmichaelii (prepared parent root) and Aconitum kusnezoffii (prepared root). |
| WOS关键词 | TANDEM MASS-SPECTROMETRY ; SINGLE ; METABOLOMICS ; TOXICITY ; ROOTS ; FUZI |
| 资助项目 | project of Standardization of Traditional Chinese Medicines/Indigenous Drugs - Chinese Academy of Sciences[KSZD-EW-Z-004-01] |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5988711 |
| WOS记录号 | WOS:000402468900008 |
| 出版者 | CHINESE JOURNAL NATURAL MEDICINES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272712]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Wu Wan-Ying |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Tradit Chinese Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang Yi-Bei,Da Juan,Zhang Jing-Xian,et al. A feasible, economical, and accurate analytical method for simultaneous determination of six alkaloid markers in Aconiti Lateralis Radix Praeparata from different manufacturing sources and processing ways[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2017,15(4):301-309. |
| APA | Zhang Yi-Bei.,Da Juan.,Zhang Jing-Xian.,Li Shang-Rong.,Chen Xin.,...&Guo De-An.(2017).A feasible, economical, and accurate analytical method for simultaneous determination of six alkaloid markers in Aconiti Lateralis Radix Praeparata from different manufacturing sources and processing ways.CHINESE JOURNAL OF NATURAL MEDICINES,15(4),301-309. |
| MLA | Zhang Yi-Bei,et al."A feasible, economical, and accurate analytical method for simultaneous determination of six alkaloid markers in Aconiti Lateralis Radix Praeparata from different manufacturing sources and processing ways".CHINESE JOURNAL OF NATURAL MEDICINES 15.4(2017):301-309. |
入库方式： OAI收割
来源：上海药物研究所
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