Identification of major xanthones and steroidal saponins in rat urine by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry technology following oral administration of Rhizoma Anemarrhenae decoction
文献类型：期刊论文
| 作者 | Ma, Chunhui1; Wang, Longxing2; Tang, Yihong1; Fan, Mingsong1; Xia, Hongbin2; Huang, Chenggang1
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| 刊名 | BIOMEDICAL CHROMATOGRAPHY
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| 出版日期 | 2008-10 |
| 卷号 | 22期号:10页码:1066-1083 |
| 关键词 | Rhizoma Anemarrhenae Anemarrhena asphodeloides xanthone steroidal saponin urine |
| ISSN号 | 0269-3879 |
| DOI | 10.1002/bmc.1026 |
| 文献子类 | Article |
| 英文摘要 | Rhizoma Anemarrhenae (Zhimu in Chinese), the dried rhizome of Anemarrhena asphodeloides Bge. (Fam. Liliaceae), is a well-known traditional Chinese medicinal herb and has been used clinically in China for centuries to cure various diseases. However, like other traditional Chinese medicines, the effective constituents of this medicine, especially the assimilation and metabolites in vivo, which are very important to show their effects, have not been systematically studied. In this paper, solid-phase extraction and liquid chromatography-atmospheric pressure chemical ionization mass spectrometry technologies were used to study the constituents absorbed into rat urine and their metabolites after oral administration of Rhizoma Anemarrhenae decoction. A total of 11 compounds, including two xanthones, three of their metabolites and six steroidal saponins, were identified in rat urine sample. They were neomangiferin (1), glucuronide and monomethyl conjugate of mangiferin (2), mangiferin (3), monomethyl conjugate of mangiferin (4), dimethyl conjugate of mangiferin (5), timosaponin N or timosaponin E1 (6), timosaponin 1311 (7), timosaponin BIII (8), anemarrhenasaponin I or anemarrhenasaponin II (9), timosaponin AII (10) and timosaponin AIII (11). The results would efficaciously narrow the potentially active compounds range in Rhizoma Anemarrhenae decoction, and pave a helpful way for follow-up mechanism of action research. Copyright (C) 2008 John Wiley & Sons, Ltd. |
| WOS关键词 | ASPHODELOIDES BUNGE LILIACEAE ; SUPEROXIDE GENERATION ; LC-MS/MS ; PLATELET-AGGREGATION ; HUMAN NEUTROPHILS ; HUMAN BLOOD ; METABOLITES ; MANGIFERIN ; EXTRACT ; MS |
| 资助项目 | National Natural Science Foundation of China[30701037] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000260522400004 |
| 出版者 | JOHN WILEY & SONS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272789]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Xia, Hongbin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Dalian Inst Chem Phys, Med Chem Lab, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Chunhui,Wang, Longxing,Tang, Yihong,et al. Identification of major xanthones and steroidal saponins in rat urine by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry technology following oral administration of Rhizoma Anemarrhenae decoction[J]. BIOMEDICAL CHROMATOGRAPHY,2008,22(10):1066-1083. |
| APA | Ma, Chunhui,Wang, Longxing,Tang, Yihong,Fan, Mingsong,Xia, Hongbin,&Huang, Chenggang.(2008).Identification of major xanthones and steroidal saponins in rat urine by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry technology following oral administration of Rhizoma Anemarrhenae decoction.BIOMEDICAL CHROMATOGRAPHY,22(10),1066-1083. |
| MLA | Ma, Chunhui,et al."Identification of major xanthones and steroidal saponins in rat urine by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry technology following oral administration of Rhizoma Anemarrhenae decoction".BIOMEDICAL CHROMATOGRAPHY 22.10(2008):1066-1083. |
入库方式： OAI收割
来源：上海药物研究所
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