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Tonkinensines A and B, two novel alkaloids from Sophora tonkinensis

文献类型：期刊论文

作者Li, Xing-Nuo1,2; Lu, Zhi-Qiang2; Qin, Song2; Yan, Hai-Xia1; Yang, Min2; Guan, Shu-Hong2; Liu, Xuan2; Hua, Hui-Ming1; Wu, Li-Jun1; Guo, De-An2
刊名TETRAHEDRON LETTERS
出版日期2008-06-02
卷号49期号:23页码:3797-3801
关键词Sophora tonkinensis quinolizidine alkaloids tonkinensine A tonkinensine B
ISSN号0040-4039
DOI10.1016/j.tetlet.2008.04.003
文献子类Article
英文摘要Tonkinensines A (1) and B (2), two novel cytisine-type alkaloids that feature the skeleton with a linkage to pterocarpan, were isolated from the roots of Sophora tonkinensis. Their structures and absolute configurations were elucidated by spectroscopic methods, especially X-ray crystal diffraction and CD spectral analysis. The proposed biosynthetic pathway was also discussed. Both 1 and 2 were tested in HeLa and MDA-MB-231 tumor cell lines, and compound 2 showed moderate cytotoxic activity. (C) 2008 Elsevier Ltd. All rights reserved.
WOS关键词ANTI-HIV ACTIVITY ; H-3 CYTISINE ; PTEROCARPANS ; BINDING ; BRAIN
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000256378800022
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/272896]  
专题上海中药现代化研究中心
通讯作者Guo, De-An
作者单位1.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Li, Xing-Nuo,Lu, Zhi-Qiang,Qin, Song,et al. Tonkinensines A and B, two novel alkaloids from Sophora tonkinensis[J]. TETRAHEDRON LETTERS,2008,49(23):3797-3801.
APA Li, Xing-Nuo.,Lu, Zhi-Qiang.,Qin, Song.,Yan, Hai-Xia.,Yang, Min.,...&Guo, De-An.(2008).Tonkinensines A and B, two novel alkaloids from Sophora tonkinensis.TETRAHEDRON LETTERS,49(23),3797-3801.
MLA Li, Xing-Nuo,et al."Tonkinensines A and B, two novel alkaloids from Sophora tonkinensis".TETRAHEDRON LETTERS 49.23(2008):3797-3801.

入库方式： OAI收割

来源：上海药物研究所

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