Salvianolic acids prevent acute doxorubicin cardiotoxicity in mice through suppression of oxidative stress
文献类型：期刊论文
| 作者 | Jiang, Baohong2 ; Zhang, Lin2; Li, Ming2; Wu, Wanying2; Yang, Min2; Wang, Junchen1; Guo, De-an2
|
| 刊名 | FOOD AND CHEMICAL TOXICOLOGY
 |
| 出版日期 | 2008-05 |
| 卷号 | 46期号:5页码:1510-1515 |
| 关键词 | salvianolic acids doxorubicin cardioprotection free radical |
| ISSN号 | 0278-6915 |
| DOI | 10.1016/j.fct.2007.12.020 |
| 文献子类 | Article |
| 英文摘要 | Although doxorubicin is an effective antitumor agent, the serious cardiotoxicity mediated by the production of reactive oxygen species has remained a considerable clinical problem. In China, salvianolic acids has been widely used for cardioprotection. To test whether salvianolic acids holds the potential to be protective against cardiotoxicity of doxorubicin, we created an acute cardiac injury mice model. Therapeutic treatment with salvianolic acids (40 mg/kg for 3 connective days) significantly reduced doxorubicin-induced (15 mg/kg) toxicity, including elevation of body weight and heart weight/tibia length ratio, decrease of creatine kinase, improvement of electrocardiography and heart vacuolation. Furthermore, the antioxidative effects of salvianolic acids were verified by oxygen radicals absorbance capacities assay in vitro and malondialdehyde detection in vivo, suggesting one possible mechanism of salvianolic acids on cardioprotection through blocking oxidative stress. (C) 2007 Elsevier Ltd. All rights reserved. |
| WOS关键词 | IN-VIVO ; PHENOLIC-ACIDS ; DNA-DAMAGE ; RATS ; DANSHEN ; MILTIORRHIZA ; APOPTOSIS ; CELLS ; VITRO ; MASS |
| WOS研究方向 | Food Science & Technology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000255328400012 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272927]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Guo, De-an |
| 作者单位 | 1.Tongji Univ, Dongfang Hosp, Dept Pathol, Shanghai 200120, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Jiang, Baohong,Zhang, Lin,Li, Ming,et al. Salvianolic acids prevent acute doxorubicin cardiotoxicity in mice through suppression of oxidative stress[J]. FOOD AND CHEMICAL TOXICOLOGY,2008,46(5):1510-1515. |
| APA | Jiang, Baohong.,Zhang, Lin.,Li, Ming.,Wu, Wanying.,Yang, Min.,...&Guo, De-an.(2008).Salvianolic acids prevent acute doxorubicin cardiotoxicity in mice through suppression of oxidative stress.FOOD AND CHEMICAL TOXICOLOGY,46(5),1510-1515. |
| MLA | Jiang, Baohong,et al."Salvianolic acids prevent acute doxorubicin cardiotoxicity in mice through suppression of oxidative stress".FOOD AND CHEMICAL TOXICOLOGY 46.5(2008):1510-1515. |
入库方式： OAI收割
来源：上海药物研究所
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