中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Salvianolic acids prevent acute doxorubicin cardiotoxicity in mice through suppression of oxidative stress

文献类型:期刊论文

作者Jiang, Baohong2; Zhang, Lin2; Li, Ming2; Wu, Wanying2; Yang, Min2; Wang, Junchen1; Guo, De-an2
刊名FOOD AND CHEMICAL TOXICOLOGY
出版日期2008-05
卷号46期号:5页码:1510-1515
关键词salvianolic acids doxorubicin cardioprotection free radical
ISSN号0278-6915
DOI10.1016/j.fct.2007.12.020
文献子类Article
英文摘要Although doxorubicin is an effective antitumor agent, the serious cardiotoxicity mediated by the production of reactive oxygen species has remained a considerable clinical problem. In China, salvianolic acids has been widely used for cardioprotection. To test whether salvianolic acids holds the potential to be protective against cardiotoxicity of doxorubicin, we created an acute cardiac injury mice model. Therapeutic treatment with salvianolic acids (40 mg/kg for 3 connective days) significantly reduced doxorubicin-induced (15 mg/kg) toxicity, including elevation of body weight and heart weight/tibia length ratio, decrease of creatine kinase, improvement of electrocardiography and heart vacuolation. Furthermore, the antioxidative effects of salvianolic acids were verified by oxygen radicals absorbance capacities assay in vitro and malondialdehyde detection in vivo, suggesting one possible mechanism of salvianolic acids on cardioprotection through blocking oxidative stress. (C) 2007 Elsevier Ltd. All rights reserved.
WOS关键词IN-VIVO ; PHENOLIC-ACIDS ; DNA-DAMAGE ; RATS ; DANSHEN ; MILTIORRHIZA ; APOPTOSIS ; CELLS ; VITRO ; MASS
WOS研究方向Food Science & Technology ; Toxicology
语种英语
WOS记录号WOS:000255328400012
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/272927]  
专题上海中药现代化研究中心
通讯作者Guo, De-an
作者单位1.Tongji Univ, Dongfang Hosp, Dept Pathol, Shanghai 200120, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714
Jiang, Baohong,Zhang, Lin,Li, Ming,et al. Salvianolic acids prevent acute doxorubicin cardiotoxicity in mice through suppression of oxidative stress[J]. FOOD AND CHEMICAL TOXICOLOGY,2008,46(5):1510-1515.
APA Jiang, Baohong.,Zhang, Lin.,Li, Ming.,Wu, Wanying.,Yang, Min.,...&Guo, De-an.(2008).Salvianolic acids prevent acute doxorubicin cardiotoxicity in mice through suppression of oxidative stress.FOOD AND CHEMICAL TOXICOLOGY,46(5),1510-1515.
MLA Jiang, Baohong,et al."Salvianolic acids prevent acute doxorubicin cardiotoxicity in mice through suppression of oxidative stress".FOOD AND CHEMICAL TOXICOLOGY 46.5(2008):1510-1515.

入库方式: OAI收割

来源:上海药物研究所

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