Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation
文献类型：期刊论文
| 作者 | Shi, Lei2; Zhang, Wei2; Zhou, Yue-Yang2; Zhang, Yi-Nan1; Li, Jing-Ya2 ; Hu, Li-Hong1; Li, Jia2
|
| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2008-04-14 |
| 卷号 | 584期号:1页码:21-29 |
| 关键词 | corosolic acid traditional Chinese medicinal herbs insulin receptor protein tyrosine phosphatase glucose uptake |
| ISSN号 | 0014-2999 |
| DOI | 10.1016/j.ejphar.2008.01.020 |
| 文献子类 | Article |
| 英文摘要 | Corosolic acid, a triterpenoid compound widely existing in many traditional Chinese medicinal herbs, has been proved to have antidiabetic effects on animal experiments and clinical trials. However, the underlying mechanisms remain unknown. Here, we investigate its cellular effects and related signaling pathway. We demonstrate that it enhances glucose uptake in L6 myotubes and facilitates glucose transporter isoform 4 translocation in CHO/hIR cells. These actions are mediated by insulin pathway activation and can be blocked by phosphatidylinositol 3-kinase (PI3 Kinase) inhibitor Wortmannin. Furthermore, Corosolic acid inhibits the enzymatic activities of several diabetes-related non-receptor protein tyrosine pbosphatases (PTPs) in vitro, such as PTP1B, T-cell-PTP, src homology phosphatase-1 and src homology phosphatase-2. (c) 2008 Elsevier B.V. All rights reserved. |
| WOS关键词 | PROTEIN-TYROSINE PHOSPHATASES ; SIGNAL-TRANSDUCTION ; METABOLIC SYNDROME ; DIABETES-MELLITUS ; MUSCLE ; COMPLICATIONS ; TRITERPENES ; EXPRESSION ; TRANSPORT ; OBESITY |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000255583300003 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272940]  |
| 专题 | 国家新药筛选中心 上海中药现代化研究中心 |
| 通讯作者 | Li, Jia |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China 2.Natl Ctr Drug Screening, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Shi, Lei,Zhang, Wei,Zhou, Yue-Yang,et al. Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2008,584(1):21-29. |
| APA | Shi, Lei.,Zhang, Wei.,Zhou, Yue-Yang.,Zhang, Yi-Nan.,Li, Jing-Ya.,...&Li, Jia.(2008).Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation.EUROPEAN JOURNAL OF PHARMACOLOGY,584(1),21-29. |
| MLA | Shi, Lei,et al."Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation".EUROPEAN JOURNAL OF PHARMACOLOGY 584.1(2008):21-29. |
入库方式： OAI收割
来源：上海药物研究所
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