Interaction of salvianolic acids and notoginsengnosides in inhibition of ADP-induced platelet aggregation
文献类型：期刊论文
| 作者 | Yao, Yan1,2; Wu, Wan-Ying1 ; Liu, Ai-Hua1; Deng, Shao-Sheng1; Bi, Kai-Shun2; Liu, Xuan1; Guo, De-An1
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| 刊名 | AMERICAN JOURNAL OF CHINESE MEDICINE
 |
| 出版日期 | 2008 |
| 卷号 | 36期号:2页码:313-328 |
| 关键词 | synergism salvianolic acids notoginsengnosides ADP platelet aggregation |
| ISSN号 | 0192-415X |
| DOI | 10.1142/S0192415X08005795 |
| 文献子类 | Article |
| 英文摘要 | Salvia miltiorrhiza and Panax notoginseng were both considered to be beneficial to cardiovascular diseases in traditional Chinese medicine and often used in combination. To examine the possible interaction between them, the effects of the active fractions of these two herbs, salvianolic acids (SA) and notoginsengnosides (NG), on platelet aggregation were checked respectively or in combination in vitro and in vivo. Both the platelet aggregation of platelet rich plasma (PRP) and washed platelet after ADP induction were checked. In vitro study showed that both SA and NG had an inhibitory effect on platelet aggregation. However, there is no synergistic effect of the combination of SA and NG in vitro. In vivo study showed that i.g. 550 mg/kg/day SA or NG for 5 days could significantly inhibit ADP-induced platelet aggregation of PRP. Moreover, combination of SA and NG at a ratio of 5: 1 had a synergistic effect on platelet aggregation of PRP. The mechanism for the synergism of SA and NG in vivo was not clear. High performance liquid chromatography analysis of the plasma of rats received SA, NG or combination of SA and NG showed that co-administration of NG caused change in the plasma distribution pro. le of SA. The influence of combination on the absorption and/or metabolism of SA may be one of the reasons for the synergism of SA and NG in vivo. |
| WOS关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY ; PANAX-NOTOGINSENG ; SIMULTANEOUS QUANTIFICATION ; GINSENG SAPONINS ; ACTIVE SAPONINS ; BLOOD-PLATELETS ; PHENOLIC-ACIDS ; HPLC-DAD ; MILTIORRHIZA ; RATS |
| WOS研究方向 | Integrative & Complementary Medicine ; General & Internal Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000255524400008 |
| 出版者 | WORLD SCIENTIFIC PUBL CO PTE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273007]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Liu, Xuan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; 2.Shenyang Pharmaceut Univ, Shenyang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yao, Yan,Wu, Wan-Ying,Liu, Ai-Hua,et al. Interaction of salvianolic acids and notoginsengnosides in inhibition of ADP-induced platelet aggregation[J]. AMERICAN JOURNAL OF CHINESE MEDICINE,2008,36(2):313-328. |
| APA | Yao, Yan.,Wu, Wan-Ying.,Liu, Ai-Hua.,Deng, Shao-Sheng.,Bi, Kai-Shun.,...&Guo, De-An.(2008).Interaction of salvianolic acids and notoginsengnosides in inhibition of ADP-induced platelet aggregation.AMERICAN JOURNAL OF CHINESE MEDICINE,36(2),313-328. |
| MLA | Yao, Yan,et al."Interaction of salvianolic acids and notoginsengnosides in inhibition of ADP-induced platelet aggregation".AMERICAN JOURNAL OF CHINESE MEDICINE 36.2(2008):313-328. |
入库方式： OAI收割
来源：上海药物研究所
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