Microbial transformation of ginsenoside Rb-1 by Acremonium strictum
文献类型：期刊论文
| 作者 | Chen, Guang-Tong1,2; Yang, Min2; Song, Yan1; Lu, Zhi-Qiang2; Zhang, Jin-Qiang2; Huang, Hui-Lian2; Wu, Li-Jun1; Guo, De-An2
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| 刊名 | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
 |
| 出版日期 | 2008-01 |
| 卷号 | 77期号:6页码:1345-1350 |
| 关键词 | ginsenoside Rb-1 biotransformation Acremonium strictum |
| ISSN号 | 0175-7598 |
| DOI | 10.1007/s00253-007-1258-4 |
| 文献子类 | Article |
| 英文摘要 | Preparative-scale fermentation of ginsenoside Rb-1 (1) with Acremonium strictum AS 3.2058 gave three new compounds, 12 beta-hydroxydammar-3-one-20 (S)-O-beta-D-glucopyranoside (7), 12 beta, 25-dihydroxydammar-(E)-20(22)-ene-3-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranoside (8), and 12 beta, 20 (R), 25-trihydroxydammar-3-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranoside (9), along with five known compounds, ginsenoside Rd (2), gypenoside XVII (3), ginsenoside Rg(3) (4), ginsenoside F-2 (5), and compound K (6). The structural elucidation of these metabolites was based primarily on one- and two-dimensional nuclear magnetic resonance and high-resolution electron spray ionization mass spectra analyses. Among these compounds, 2-6 are also the metabolites of ginsenoside Rb-1 in mammals. This result demonstrated that microbial culture parallels mammalian metabolism; therefore, A. strictum might be a useful tool for generating mammalian metabolites of related analogs of ginsenosides for complete structural identification and for further use in pharmaceutical research in this series of compounds. In addition, the biotransformation kinetics was also investigated. |
| WOS关键词 | TANDEM MASS-SPECTROMETRY ; MAMMALIAN METABOLISM ; PANAX-NOTOGINSENG ; PENICILLIUM-JANTHINELLUM ; TRITERPENE SAPONINS ; MODELS ; RAT ; IDENTIFICATION |
| WOS研究方向 | Biotechnology & Applied Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000252293300017 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273008]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Guo, De-An |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai Res Inst Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Chen, Guang-Tong,Yang, Min,Song, Yan,et al. Microbial transformation of ginsenoside Rb-1 by Acremonium strictum[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2008,77(6):1345-1350. |
| APA | Chen, Guang-Tong.,Yang, Min.,Song, Yan.,Lu, Zhi-Qiang.,Zhang, Jin-Qiang.,...&Guo, De-An.(2008).Microbial transformation of ginsenoside Rb-1 by Acremonium strictum.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,77(6),1345-1350. |
| MLA | Chen, Guang-Tong,et al."Microbial transformation of ginsenoside Rb-1 by Acremonium strictum".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 77.6(2008):1345-1350. |
入库方式： OAI收割
来源：上海药物研究所
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