Cytotoxic triterpenoid saponins from Vaccaria segetalis
文献类型：期刊论文
| 作者 | Ma, Chun-Hui; Fan, Ming-Song; Lin, Li-Ping; Tang, Wei-Dong; Lou, Li-Guang ; Ding, Jian; Huang, Cheng-Gang
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| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
 |
| 出版日期 | 2008 |
| 卷号 | 10期号:2页码:177-184 |
| 关键词 | Vaccaria segetalis Vaccaria pyramidata triterpenoid saponin quillaic acid vaccaroside I cytotoxic activity |
| ISSN号 | 1028-6020 |
| DOI | 10.1080/10286020701394381 |
| 文献子类 | Article |
| 英文摘要 | By the guidance of bioassay, one new cytotoxic triterpenoid saponin, 3-O-[beta-D-galactopyranosyl(1 -> 2)-beta-D-glucuronopyranosyl] quillaic acid 28-O-beta-D- glucopyranosyl-(1 -> 3)-beta-D-xylopyranosyl(1 -> 4)-alpha-L-rhamnopyranosyl-(1 -> 2)-[beta-D-fucopyranosyl-(1 -> 4)]-beta-D-fucopyranoside (1), and five known cytotoxic triterpenoid saponins, vaccaroside E (2), vaccaroside G (3), vaccaroside B (4), segetoside H (5) and segetoside I (6), were isolated from Vaccaria segetalis. Their structures were established on the basis of ESI-MS, IR, extensive NMR ((1)H NMR, (13)C NMR, TOCSY, (1)H-(1)H COSY, DEPT, HMQC, HMBC and ROESY) analyses, chemical degradation, and by comparing with previously reported data. Compounds 1-6 showed moderate cytotoxic activities against LNcap, P-388 and A-549 cell lines with IC(50) values in the range 0.1-12.9 mu M. |
| WOS关键词 | ESTROGEN-LIKE ACTIVITY ; CYCLIC-PEPTIDES ; SEEDS ; ASSAY ; CELL |
| WOS研究方向 | Plant Sciences ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000256384400011 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273046]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Huang, Cheng-Gang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Chun-Hui,Fan, Ming-Song,Lin, Li-Ping,et al. Cytotoxic triterpenoid saponins from Vaccaria segetalis[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2008,10(2):177-184. |
| APA | Ma, Chun-Hui.,Fan, Ming-Song.,Lin, Li-Ping.,Tang, Wei-Dong.,Lou, Li-Guang.,...&Huang, Cheng-Gang.(2008).Cytotoxic triterpenoid saponins from Vaccaria segetalis.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,10(2),177-184. |
| MLA | Ma, Chun-Hui,et al."Cytotoxic triterpenoid saponins from Vaccaria segetalis".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 10.2(2008):177-184. |
入库方式： OAI收割
来源：上海药物研究所
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