Identification and determination of four metabolites of mangiferin in rat urine
文献类型：期刊论文
| 作者 | Wang, Hui; Ye, Guan; Ma, Chun-Hui; Tang, Yi-Hong; Fan, Ming-Song; Li, Zhi-Xiong ; Huang, Cheng-Gang
|
| 刊名 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
 |
| 出版日期 | 2007-12-21 |
| 卷号 | 45期号:5页码:793-798 |
| 关键词 | mangiferin metabolite HPLC urine |
| ISSN号 | 0731-7085 |
| DOI | 10.1016/j.jpba.2007.07.019 |
| 文献子类 | Article |
| 英文摘要 | Four metabolites of mangiferin were firstly isolated and identified from rat urine. The structures of the four metabolites were determined to be 1,3,7-trihydroxyxanthone (M-1), 1,3,6,7-tetrahydroxyxanthone (M-2), 1,3,6-trihydroxy-7-methoxyxanthone (M-3) and 1,7-dihydroxyxanthone (M-4), respectively. A simple and specific analytical method for determination of the four metabolites in rat urine was developed by high performance liquid chromatography (HPLC). Quercetin was employed as an internal standard. The correlation coefficients of the calibration curves were higher than 0.997, both intra- and inter-day precision of four metabolites were determined and their R.S.D. did not exceed 10%. The accuracy and linear range had been investigated in detail. The cumulative urinary excretions of the four metabolites were measured and the possible metabolic pathway of the metabolites was discussed. (c) 2007 Elsevier B.V. All rights reserved. |
| WOS关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY ; IONIZATION MASS-SPECTROMETRY ; C-GLUCOSYL BOND ; NORATHYRIOL ; XANTHONES ; MICE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000252013300014 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273090]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Huang, Cheng-Gang |
| 作者单位 | Chinese Acad Sci, Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hui,Ye, Guan,Ma, Chun-Hui,et al. Identification and determination of four metabolites of mangiferin in rat urine[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2007,45(5):793-798. |
| APA | Wang, Hui.,Ye, Guan.,Ma, Chun-Hui.,Tang, Yi-Hong.,Fan, Ming-Song.,...&Huang, Cheng-Gang.(2007).Identification and determination of four metabolites of mangiferin in rat urine.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,45(5),793-798. |
| MLA | Wang, Hui,et al."Identification and determination of four metabolites of mangiferin in rat urine".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 45.5(2007):793-798. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。