Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea
文献类型：期刊论文
| 作者 | Chen, Guangtong; Yang, Min; Lu, Zhiqiang; Zhang, Jinqiang; Huang, Huilian; Liang, Yan; Guan, Shuhong ; Song, Yan; Wu, Lijun; Guo, De-an
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2007-07 |
| 卷号 | 70期号:7页码:1203-1206 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np070053v |
| 文献子类 | Article |
| 英文摘要 | Three 20(S)-protopanaxatriol-type saponins, ginsenoside-Rg(1) (1), notoginsenoside-R-1 (2), and ginsenoside-Re (3), were transformed by the fungus Absidia coerulea (AS 3.3389). Compound 1 was converted into five metabolites, ginsenoside-Rh-4 (4), 3 beta, 2 beta, 25-trihydroxydammar-(E)-20(22)-ene-6-O-beta-D-glucopyranoside (5), 20(S)-ginsenoside-Rh-1 (6), 20(R)-ginsenoside- Rh-1(7), and a mixture of 25-hydroxy-20(S)-ginsenoside-Rh-1 and its C-20(R) epimer (8). Compound 2 was converted into 10 metabolites, 20(S)-notoginsenoside-R-2 (9), 20(R)-notoginsenoside-R-2 (10), 3 beta, 12 beta, 25-trihydroxydammar( E)-20(22)-ene-6-O-beta-D-xylopyranosyl-(1 -> 2)-beta-D-glucopyranoside (11), 3 beta, 12 beta-dihydroxydammar-(E)-20(22), 24-diene-6- O-beta-D-xylopyranosyl-(1 -> 2)-beta-D-glucopyranoside (12), 3 beta, 12 beta, 20,25-tetrahydroxydammaran-6-O-beta-D-xylopyranosyl(1 -> 2)-beta- D-glucopyranoside (13), and compounds 4-8. Compound 3 was metabolized to 20(S)-ginsenoside-Rg(2) (14), 20(R)-ginsenoside-Rg(2) (15), 3 beta, 12 beta, 25-trihydroxydammar-(E)-20(22)-ene-6-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucopyranoside (16), 3 beta, 12 beta-dihydroxydammar-(E)-20(22), 24-diene-6-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucopyranoside (17), 3 beta, 12 beta, 20,25-tetrahydroxydammaran-6-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucopyranoside (18), and compounds 4-8. The structures of five new metabolites, 10-13 and 16, were established by spectroscopic methods. |
| WOS关键词 | PANAX-NOTOGINSENG ; TRITERPENE SAPONINS ; DAMMARANE SAPONINS ; GINSENG ; LEAVES |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000248344800025 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273215]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Guo, De-an |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Guangtong,Yang, Min,Lu, Zhiqiang,et al. Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea[J]. JOURNAL OF NATURAL PRODUCTS,2007,70(7):1203-1206. |
| APA | Chen, Guangtong.,Yang, Min.,Lu, Zhiqiang.,Zhang, Jinqiang.,Huang, Huilian.,...&Guo, De-an.(2007).Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea.JOURNAL OF NATURAL PRODUCTS,70(7),1203-1206. |
| MLA | Chen, Guangtong,et al."Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea".JOURNAL OF NATURAL PRODUCTS 70.7(2007):1203-1206. |
入库方式： OAI收割
来源：上海药物研究所
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