L-stepholidine blocks methamphetamine-induced locomotor sensitization in mice
文献类型：会议论文
| 作者 | Ma, Bao Miao3; Yue, Kai3; Xing, Jun Qiao3; Gong, Xiao Kang3; Ru, Qin3; Chen, Lin3; Xiong, Qi3; Tian, Xiang3; Liu, Lu3; Gan, Yong Qing1 |
| 出版日期 | 2014 |
| 卷号 | 998-999 |
| DOI | 10.4028/www.scientific.net/AMR.998-999.156 |
| 页码 | 156-159 |
| 英文摘要 | Repeating administration of methamphetamine (METH) can result in locomotor sensitization, a progressive increase in their psychomotor activating effects. l-Stepholidine (l-SPD), an alkaloid extract of the Chinese herb Stephania intermedia, is the first compound known to exhibit mixed dopamine D1 receptor agonist/D2 antagonist properties and is a potential medication for the treatment of drug addiction. Therefore, the effects of l-SPD on the hyperactivity, development and expression of METH-induced locomotor sensitization were investigated. The results indicated that l-SPD dose-dependently inhibited hyperlocomotion induced by acute METH and prevented the sensitized motor behavior induced by chronic METH administration. l-SPD likely acts as a D1 partial agonist and a D2 antagonist to produce its in vivo effects and may be a promising agent for treatment of METH addiction. |
| 会议录 | Advanced Materials Research
 |
| 会议录出版者 | Trans Tech Publications Ltd |
| 文献子类 | Proceedings Paper |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266846]  |
| 专题 | 院士及顾问专家 |
| 通讯作者 | Li, Chao Ying |
| 作者单位 | 1.Drug Prevention and Education Center, Hubei Public Security Bureau, Wuhan 430070, China; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201213, China 3.Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan 430056, China; |
| 推荐引用方式 GB/T 7714 | Ma, Bao Miao,Yue, Kai,Xing, Jun Qiao,et al. L-stepholidine blocks methamphetamine-induced locomotor sensitization in mice[C]. 见:. |
入库方式： OAI收割
来源：上海药物研究所
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