L-stepholidine, a naturally occurring dopamine D1 receptor agonist and D2 receptor antagonist, attenuates methamphetamine self-administration in rats
文献类型：会议论文
| 作者 | Yue, Kai3; Ma, Bao Miao3; Xing, Jun Qiao3; Gong, Xiao Kang3; Ru, Qin3; Chen, Lin3; Xiong, Qi3; Tian, Xiang3; Liu, Lu3; Gan, Yong Qing2 |
| 出版日期 | 2014 |
| 卷号 | 998-999 |
| DOI | 10.4028/www.scientific.net/AMR.998-999.169 |
| 页码 | 169-172 |
| 英文摘要 | Given the problems associated with the escalation in methamphetamine (METH) use, the identification of more effective treatment strategies is essential. l-stepholidine (l-SPD) is an alkaloid extract of the Chinese herb Stephania intermedia with dopamine D1 receptor partial agonistic and D2 receptor antagonistic dual actions. The unique pharmacological profile of l-SPD suggests that l-SPD may be effective for the treatment of METH addiction. The aim of this study was to characterize the effect of l-SPD on METH self-administration on a fixed-ratio 1 schedule. We found that 5 and 10 mg/kg of l-SPD attenuated METH self-administration behavior. These results demonstrate that l-SPD which possesses dual actions on dopamine D1 and D2 receptors, attenuates METH self-administration on a fixed-ratio 1 schedule. |
| 会议录 | Advanced Materials Research
 |
| 会议录出版者 | Trans Tech Publications Ltd |
| 文献子类 | Proceedings Paper |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266852]  |
| 专题 | 院士及顾问专家 |
| 通讯作者 | Li, Chao Ying |
| 作者单位 | 1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201213, China 2.Drug Prevention and Education Center, Hubei Public Security Bureau, Wuhan 430070, China; 3.Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan 430056, China; |
| 推荐引用方式 GB/T 7714 | Yue, Kai,Ma, Bao Miao,Xing, Jun Qiao,et al. L-stepholidine, a naturally occurring dopamine D1 receptor agonist and D2 receptor antagonist, attenuates methamphetamine self-administration in rats[C]. 见:. |
入库方式： OAI收割
来源：上海药物研究所
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