Levo-tetrahydropalmatine, a naturally occurring dopamine receptor antagonist, attenuates cue-induced reinstatement of heroin seeking in rats
文献类型：会议论文
| 作者 | Yue, Kai2; Ma, Baomiao2; Ru, Qin2; Chen, Lin2; Tian, Xiang2; Gan, Yongping1; Wang, Daisong1; Jin, Guozhang2,3 ; Li, Chaoying2
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| 出版日期 | 2014 |
| 卷号 | 18 |
| DOI | 10.2495/HHME130531 |
| 页码 | 411-417 |
| 英文摘要 | Levo-tetrahydropalmatine (l-THP) is an alkaloid substance extracted from Corydalis and Stephania and is contained in a number of traditional Chinese herbal preparations. l-THP has lower affinity for D2 receptors than for D1 receptors. The unique pharmacological profile of l-THP suggests that l-THP may be effective for the treatment of opiate addiction. The aim of this study was to characterize the effect of l-THP on cue-induced reinstatement of heroin seeking under an extinction/reinstatement protocol. We found that 1.25, 2.5, and 5 mg/kg of l-THP attenuated cue-induced reinstatement of heroin seeking behavior. These results demonstrated that l-THP has therapeutic utility for the treatment of heroin addiction. |
| 会议录 | WIT Transactions on Biomedicine and Health
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| 会议录出版者 | WITPress |
| 文献子类 | Proceedings Paper |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266853]  |
| 专题 | 院士及顾问专家 |
| 作者单位 | 1.Drug Prevention and Education Center, Hubei Public Security Bureau, Wuhan, China; 2.Wuhan Institute of Biomedical Sciences, Jianghan University, Wuhan, China; 3.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China |
| 推荐引用方式 GB/T 7714 | Yue, Kai,Ma, Baomiao,Ru, Qin,et al. Levo-tetrahydropalmatine, a naturally occurring dopamine receptor antagonist, attenuates cue-induced reinstatement of heroin seeking in rats[C]. 见:. |
入库方式： OAI收割
来源：上海药物研究所
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