Total synthesis of()-stepholidine
文献类型：期刊论文
| 作者 | LOU Yuan-yuan1; LI Jian-feng2 ; WEI Ya-bing1
|
| 刊名 | Chinese Journal of Medicinal Chemistry
 |
| 出版日期 | 2009 |
| 卷号 | 19期号:5页码:361 |
| 关键词 | Bischler-Napieralski环合 process improvement stepholidine schizophrenia Bischler-Napieralski cyclization |
| ISSN号 | 1005-0108 |
| 其他题名 | 千金藤啶碱的全合成 |
| 文献子类 | Article |
| 英文摘要 | Aim To study and improve the total synthesis of ()-stepholidine(SPD).Methods 3-Hydroxy-4-benzyloxyphenylacetic acid was cyclized with formaldehyde and methylated to give compound 3,which was condensed with 3-methoxy-4-benzyloxyphenethylamine to obtain amide(5).Compound 5 was subjected to Bischler-Napieralski cyclization followed by NaBH_4 reduction giving tetrahydrobeberine(6),which was hydrogenated with Raney-Ni to get SPD.Results and conclusion This method is short in steps and easy to control.And it avoids the use of dangerous diazomethane,the structure of target compound stepholidine and its intermediates were identified by ~1H-NMR and MS. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3699580 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267990]  |
| 专题 | 科研与新药推进处 |
| 作者单位 | 1.College of Materials Science and Engineering, Nanjing University of Technology, Nanjing, Jiangsu 210009, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | LOU Yuan-yuan,LI Jian-feng,WEI Ya-bing. Total synthesis of()-stepholidine[J]. Chinese Journal of Medicinal Chemistry,2009,19(5):361. |
| APA | LOU Yuan-yuan,LI Jian-feng,&WEI Ya-bing.(2009).Total synthesis of()-stepholidine.Chinese Journal of Medicinal Chemistry,19(5),361. |
| MLA | LOU Yuan-yuan,et al."Total synthesis of()-stepholidine".Chinese Journal of Medicinal Chemistry 19.5(2009):361. |
入库方式： OAI收割
来源：上海药物研究所
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