Effect of(-)-stepholidine on enhancing cardiac muscle contraction mediated by dopamine D1 receptor
文献类型：期刊论文
| 作者 | Shuyuan Zhou1; Zhen Shi1; Zheng Liu1; Huisheng Hu1; Xiaodong Li1; Jin Guozhang2 ; Long Chen1
|
| 刊名 | Pharmacology and Clinics of Chinese Materia Medica
 |
| 出版日期 | 2009 |
| 卷号 | 25期号:2页码:23-26 |
| 关键词 | (-)-stepholidine dopamine D, receptor isolated rat working heart L-type Ca~(2+) current |
| ISSN号 | 1001-859X |
| 其他题名 | 左旋千金藤啶碱增加离体大鼠心肌收缩力的作用 |
| 文献子类 | Article |
| 英文摘要 | Objective:The present study was undertaken to investigate the effect of (-)-Stepholidine (SPD) on enhancing L-type Ca~(2+) current and contraction of cardiac muscle in isolated rat heart mediated by dopamine D_1 receptor and to examine whether SPD has a direct effect on the heart dopamine D_1 receptors.Methods:Normal adult rat working hearts by Langendorff and patch clamp techniques were applied to investigate the effects of SPD on left ventricular pressure and L-type Ca~(2+) current.Results:SPD significantly increased the cardiac muscle contraction and L-type Ca~(2+) current in a dose-dependent manner.The selective dopamine D_1 receptor antagonist SCH23390 (1 muM) blocked the SPD induced heart contraction effect.However,beta-receptor antagonist propranolol (1 muM),alphal-receptor antagonist prazosin (1 muM) and Hl-receptor antagonist Fexofenadine (1 muM) had no effects in blocking SPD induced heart contractions.Conclusions:SPD exerted its effect on enhancing contraction of isolated rat heart through activating heart dopamine D_1 receptor mediated by L-type Ca~(2+) channel. |
| 资助项目 | 江苏省教育厅自然科学基础研究基金[00000000] ; 南京市留学归国人员基金(2006)[00000000] ; 江苏省教育厅国家重点实验室培育点-针药结合实验室[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3748975 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268002]  |
| 专题 | 院士及顾问专家 |
| 作者单位 | 1.Research Center of Acupuncture and Pharmacology,Institute of traditional Chinese Medicine, Nanjing, Jiangsu 210029, China.; 2.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Shuyuan Zhou,Zhen Shi,Zheng Liu,et al. Effect of(-)-stepholidine on enhancing cardiac muscle contraction mediated by dopamine D1 receptor[J]. Pharmacology and Clinics of Chinese Materia Medica,2009,25(2):23-26. |
| APA | Shuyuan Zhou.,Zhen Shi.,Zheng Liu.,Huisheng Hu.,Xiaodong Li.,...&Long Chen.(2009).Effect of(-)-stepholidine on enhancing cardiac muscle contraction mediated by dopamine D1 receptor.Pharmacology and Clinics of Chinese Materia Medica,25(2),23-26. |
| MLA | Shuyuan Zhou,et al."Effect of(-)-stepholidine on enhancing cardiac muscle contraction mediated by dopamine D1 receptor".Pharmacology and Clinics of Chinese Materia Medica 25.2(2009):23-26. |
入库方式： OAI收割
来源：上海药物研究所
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