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Action mechanism of atypical antipsychotics and vista of drug discovery

文献类型：期刊论文

作者LIU HuiFang2; FU Wei2; JIN GuoZhang1
刊名Chinese Journal of Pharmacology and Toxicology
出版日期2008
卷号22期号:6页码:470-476
关键词antipsychotics schizophrenia receptors,dopamine receptors, serotonin
ISSN号1000-3002
其他题名非经典抗精神病药作用机制及药物发现展望
文献子类Review
英文摘要In the past 10 years, atypical antipsychotics were developed to be the second generation of medicine without extrapyramidal symptoms side effects to treat schizophrenia. This paper summarizes the structural feature, therapeutic effect of several representative atypical antipsychotics and their binding mechanism with target receptors at molecular levels. In addition, it also classifies atypical antipsychotics, based on their binding mechanism with target receptors. Finally a new clue for drug design and discovery of novel atypical antipsychotics with less side effects was provided.
资助项目国家自然科学基金资助项目（20702009）[00000000] ; 中国博士点新教师基金资助课题（20070246092）[00000000]
WOS研究方向Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:3449692
源URL[http://119.78.100.183/handle/2S10ELR8/268064]  
专题院士及顾问专家
通讯作者JIN GuoZhang
作者单位1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
2.Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 200032, China.;
推荐引用方式
GB/T 7714		 LIU HuiFang,FU Wei,JIN GuoZhang. Action mechanism of atypical antipsychotics and vista of drug discovery[J]. Chinese Journal of Pharmacology and Toxicology,2008,22(6):470-476.
APA LIU HuiFang,FU Wei,&JIN GuoZhang.(2008).Action mechanism of atypical antipsychotics and vista of drug discovery.Chinese Journal of Pharmacology and Toxicology,22(6),470-476.
MLA LIU HuiFang,et al."Action mechanism of atypical antipsychotics and vista of drug discovery".Chinese Journal of Pharmacology and Toxicology 22.6(2008):470-476.

入库方式： OAI收割

来源：上海药物研究所

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